Evidence map›Paper›PMID 41526666›Full record

ArticleNPJ precision oncology2026

ShinyEvents: harmonizing longitudinal data for real-world survival estimation.

Alyssa Obermayer, Joshua Davis, Divya Priyanka Talada, Mingxiang Teng, Steven Eschrich, Vivien Yin, Daniel Spakowicz, Dipankor Chatterjee, Robert J Rounbehler, Michelle L Churchman and 12 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Alyssa ObermayerH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Alyssa.Obermayer@Moffitt.org.
Joshua DavisH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Divya Priyanka TaladaH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Mingxiang TengH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Steven EschrichH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Vivien YinH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Daniel SpakowiczThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Dipankor ChatterjeeThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Robert J RounbehlerAster Insights, Hudson, FL, USA.
Michelle L ChurchmanAster Insights, Hudson, FL, USA.
Ahmad A TarhiniH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Xuefeng WangH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Sumati GuptaHuntsman Cancer Institute, Salt Lake City, UT, USA.
Joseph MarkowitzH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Jeremy GoecksH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Roger LiH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Rodrigo Rodrigues PessoaH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Brandon J ManleyH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Aik-Choon Tan *Huntsman Cancer Institute, Salt Lake City, UT, USA.
G Daniel Grass *H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Dung-Tsa Chen *H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Timothy I Shaw *H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Timothy.Shaw@moffitt.org.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Developing a Cancer Galaxy Computational Workbench to Meet Emerging Cancer Data Analysis NeedsU24CA284167 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Jeremy Goecks · 2024 to 2026
$2.9M
Integrated Program in Cancer and Data Science (ICADS)T32CA233399 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI William Douglas Cress, Elsa R Flores · 2019 to 2026
$1.7M
Program control of CD8+ T cell response to tumors and tumor memoryR01CA293755 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Dorina Avram, Timothy Isham Shaw · 2025 to 2026
$1.1M
Development of adverse event (AE) derived biomarkers for predicting clinical outcomes in lung cancerR21CA286417 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CHEN, DUNG-TSA · 2024 to 2025
$433k
Florida Department of Health MOAAXNational Institute of Health NCI R01CA293755NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA293755NCI NIH HHS R21 CA286417NCI NIH HHS T32 CA233399NCI NIH HHS U24 CA284167NIH HHS NCI P30 CA076292NIH HHS T32 CA233399-04U.S. Department of Defense HT94252510691
6 · The paper itself

Abstract

Longitudinal data analysis of the patient's treatment course is critical to uncovering variables that influence outcomes. However, existing tools have significant limitations in integrating multilayered time-series data, particularly in linking treatment events with survival outcomes. Here, we developed ShinyEvents, a web-based framework for complex longitudinal data analysis. ShinyEvents allows users to upload data and generate interactive timelines of clinical events, enabling cohort-level analyses such as treatment clustering and endpoint assignment. It also provides informative cohort visualizations, such as a Sankey diagram of the treatment line and a Swimmer diagram of the clinical course. Finally, our tool can infer real-world progression-free survival (rwPFS) based on user-defined endpoints and perform Kaplan-Meier and Cox proportional hazards regression analysis. With these features, the tool can then associate treatment lines with clinical outcomes. As a case study, we analyzed Moffitt patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy followed by surgery. Patients treated with cisplatin and gemcitabine exhibited more favorable rwPFS and overall survival, which is consistent with prior reports. Altogether, ShinyEvents provides a unified framework for integrating longitudinal real-world data with survival analytics, fostering transparent and reproducible collaboration between clinicians and data scientists. A live demo is available at https://shawlab-moffitt.shinyapps.io/shinyevents/ .

Identifiers

PMID41526666
PMCPMC12877126

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.