Evidence map›Paper›PMID 41526628›Full record

ArticleAnnals of surgical oncology2026

Prognostic Value of Preoperative Anemia on Survival and Recurrence in Patients with Bladder Carcinoma Treated by Radical Cystectomy.

Milan Sretenovic, Uros Bumbasirevic, Nebojsa Bojanic, Otas Durutovic, Aleksandar Janicic, Boris Kajmakovic, Milos Petrovic, Petar Bulat, Sandra Sipetic Grujicic, Bogomir Milojevic

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Milan SretenovicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Uros BumbasirevicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Nebojsa BojanicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Otas DurutovicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Aleksandar JanicicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Boris KajmakovicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Milos PetrovicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Petar BulatClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia.
Sandra Sipetic GrujicicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Bogomir MilojevicClinic of Urology, University Clinical Center of Serbia, Belgrade, Serbia. em2bogomir@yahoo.com.ORCID http://orcid.org/0000-0001-6784-8389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreoperative anemia (PA) has been recognized as a potential prognostic biomarker in various urologic malignancies; however, its significance in patients with bladder carcinoma undergoing radical cystectomy (RC) remains insufficiently defined. This study aimed to evaluate the prognostic value of PA on survival and recurrence outcomes in patients treated with RC.

methodsA retrospective analysis was conducted on 299 patients who underwent RC for nonmetastatic bladder cancer between 2015 and 2018. Patients were stratified into anemia and nonanemia groups based on age- and sex-adjusted hemoglobin thresholds. Clinicopathologic characteristics were compared. The impact of PA on overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) was assessed by using Kaplan-Meier analysis and Cox proportional hazards models.

resultsPreoperative anemia was present in 159 patients (53.2%) and was significantly associated with adverse clinicopathologic factors, including higher tumor stage, higher tumor grade, lymphovascular invasion, hydronephrosis, hypoalbuminemia, and thrombocytosis (all p < 0.05). In univariate analyses, PA was associated with worse OS (hazard ratio [HR] 2.199, p < 0.001), CSS (HR 2.345, p < 0.001), and RFS (HR 1.955, p = 0.005). Multivariate analyses confirmed PA as an independent predictor of OS (HR 1.455, p = 0.022), CSS (HR 1.566, p = 0.010), and RFS (HR 1.622, p = 0.044). Kaplan-Meier curves demonstrated significantly poorer survival outcomes across all endpoints in anemic patients. The 5-year CSS estimate was 35.8% in patients with PA.

conclusionsPreoperative anemia is an independent adverse prognostic factor for survival and recurrence in patients with bladder carcinoma treated with radical cystectomy.

Indexed as

AnemiaCystectomyNeoplasm Recurrence, LocalUrinary Bladder NeoplasmsAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPreoperative PeriodPrognosisRetrospective StudiesSurvival RateBladder cancerPreoperative anemiaRadical cystectomyRecurrenceSurvival

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PMID41526628

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