Evidence map›Paper›PMID 41526596›Full record

ArticleGeroScience2026

Adoptive T-cell therapies for persistent COVID-19 in immunocompromised patients: Comparison of IFN-γ virus-specific T-cell therapy and CD45RA

László Gopcsa, Borisz Rabán Petrik, Bálint Gergely Szabó, Marienn Réti, Hajnalka Andrikovics, Ilona Bobek, Gabriella Bekő, Judit Bogyó, Andrea Ceglédi, Katalin Dobos and 14 more

Abstract readComparative Study
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

László GopcsaDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.ORCID http://orcid.org/0000-0003-4930-7049
Borisz Rabán PetrikDepartment of Infectious Diseases, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.ORCID http://orcid.org/0009-0002-5898-368X
Bálint Gergely SzabóDepartmental Group of Infectious Diseases, Department of Internal Medicine and Haematology, Semmelweis University, Üllői Út 26., 1085, Budapest, Hungary. szabo.balint.gergely@gmail.com.ORCID http://orcid.org/0000-0003-1775-1356
Marienn RétiDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.ORCID http://orcid.org/0000-0002-4682-5628
Hajnalka AndrikovicsLaboratory of Molecular Genetics, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.ORCID http://orcid.org/0000-0002-8368-9784
Ilona BobekDepartment of Intensive Care Unit, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.ORCID http://orcid.org/0000-0003-2187-4666
Gabriella BekőDepartment of Central Laboratory, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.ORCID http://orcid.org/0000-0001-8539-5897
Judit BogyóHungarian National Blood Transfusion Service, Karolina Út 19-21., 1113, Budapest, Hungary.
Andrea CeglédiDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.ORCID http://orcid.org/0000-0002-4285-7518
Katalin DobosDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.
Laura Giba-KissDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.
Orsolya KisDepartment of Intensive Care Unit, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Botond LakatosDepartment of Infectious Diseases, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.ORCID http://orcid.org/0000-0001-7276-7639
Dóra MathiászDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.
Nóra MeggyesiLaboratory of Molecular Genetics, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Gottfried MiskolcziDepartment of Central Laboratory, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Noémi NémethDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.
János SinkóDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.ORCID http://orcid.org/0000-0001-7721-6828
Anikó SzilvásiHungarian National Blood Transfusion Service, Karolina Út 19-21., 1113, Budapest, Hungary.ORCID http://orcid.org/0000-0002-4092-6073
János SzlávikDepartment of Infectious Diseases, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Szabolcs TasnádyDepartment of Central Laboratory, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.ORCID http://orcid.org/0000-0002-6736-3493
Zsuzsanna VárnaiDepartment of Infectious Diseases, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Péter ReményiDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.ORCID http://orcid.org/0009-0006-9664-9067
István Vályi-NagyDepartment of Hematology and Stem Cell Transplantation, Central Hospital of Southern-Pest, National Institute of Hematology and Infectious Diseases, 1097, Nagyvárad Square 1., Budapest, Hungary.ORCID http://orcid.org/0000-0003-3581-113X

Funding

'Project number TKP2021-EGA-08 has been implemented with support from the National Research, Development, and Innovation Fund of Hungary, financed under the 'Thematic Excellence Program 2021' funding scheme'. TKP2021-EGA-08
6 · The paper itself

Abstract

Advanced age, comorbidities, and immunocompromised states remain major risk factors for severe or persistent COVID-19 despite vaccination and antivirals, underscoring the need for innovative treatments such as adoptive T-cell therapy (ATT). In this prospective single-center study, we evaluated the safety, feasibility, and efficacy of two ATT approaches in immunocompromised patients with high-risk or persistent SARS-CoV-2 infection: interferon-γ cytokine capture system virus-specific T cells (IFN-γ CCS VST, n = 12; median age 59) and CD45RA + T-cell depleted donor lymphocyte infusion (CD45RA

Indexed as

COVID-19Immunocompromised HostImmunotherapy, AdoptiveInterferon-gammaLymphocyte TransfusionT-LymphocytesAdultAgedFemaleHematopoietic Stem Cell TransplantationHumansLeukocyte Common AntigensLymphocyte DepletionMaleMiddle AgedProspective StudiesInterferon-gammaLeukocyte Common AntigensCD45RA+ depleted donor Lymphocyte infusionComorbidityCOVID-19ElderlyHematopoietic stem cell transplantationImmunocompromisedImmunosenescenceSARS-CoV-2Virus-specific T-cells

Identifiers

PMID41526596
PMCPMC13356011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.