Evidence map›Paper›PMID 41526538›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2026

Sargassum fusiforme-derived Exosome-like Nanoparticles Suppress TLR4/MyD88/NF-κB Pathway to Alleviate Colitis via Modulating Gut Microbiota.

Hong Chang, Xinru Wang, Donglin Sui, Yi Liu, Xiaodong Xia, Ningbo Qin

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Frontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hong ChangState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, Liaoning, China.
Xinru WangState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, Liaoning, China.
Donglin SuiState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, Liaoning, China.
Yi LiuState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, Liaoning, China.
Xiaodong XiaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hom Hung, Kowloon, Hong Kong, China.
Ningbo QinState Key Laboratory of Marine Food Processing and Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, Liaoning, China. qinningbo6902765@163.com.

Funding

Basic Scientific Research Funds of Universities in Liaoning Province LJBKY2024042National Natural Science Foundation of China 32372341Science and Technology Joint Project of Liaoning Province 2024-MSLH-021
6 · The paper itself

Abstract

Plant-derived exosome-like nanoparticles (PELNs) offer both prophylactic and therapeutic potential for ulcerative colitis (UC). Following the successful isolation of Sargassum fusiforme-derived exosome-like nanoparticles (SELNs), this study investigated the protective efficacy of SELNs in mitigating Citrobacter rodentium-induced colitis. SELNs administration exhibited prolonged gut retention and colon-targeting efficacy and significantly alleviated colitis symptoms, including body weight loss, colonic shortening, and histological damage, while promoting tight junction and MUC2 protein expression. SELNs suppressed the TLR4/MyD88/NF-κB cascade, a key inflammatory pathway, resulting in downregulated pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and upregulated anti-inflammatory cytokines (IL-10, IL-22), coupled with iNOS abrogation. Furthermore, SELNs modulated the gut microbiota compositon, especially increasing the abundance of Muribaculum intestinale, and promoted the production of short-chain fatty acids (SCFAs). Collectively, these findings suggest that SELNs possess significant promise as a functional food ingredient for colitis through intestinal homeostasis modulation and inflammatory pathway regulation. Given their natural source and potent anti‑inflammatory effects, SELNs hold good potential for commercialization as a novel nutraceutical for inflammatory bowel disease intervention.

Indexed as

ColitisExosomesGastrointestinal MicrobiomeNanoparticlesAnimalsColonCytokinesEdible SeaweedsFatty Acids, VolatileMaleMiceMice, Inbred C57BLMyeloid Differentiation Factor 88NF-kappa BSargassumSignal TransductionCytokinesFatty Acids, VolatileMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseToll-Like Receptor 4Citrobacter rodentiumGut microbiotaSargassum fusiforme-derived exosome-like nanoparticles (SELNs)TLR4/MyD88/NF-κBUlcerative colitis

Identifiers

PMID41526538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.