ArticleCommunications biology2026
Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Visual perception appears largely stable in time. However, psychophysical studies have revealed that low frequency (0.5 - 7 Hz) oscillatory dynamics can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of waves around 5 Hz (theta or alpha-like) to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal persistence of visually evoked 5-Hz oscillations. This modulation of 5-Hz oscillations in both cortical areas indicates a strengthening of top-down control of perception, supporting an underlying mechanism of perceptual filling and visual hallucinations.
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