ArticleSurgical endoscopy2026
Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.
Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- [Anorectal functional disorders following organ-preserving treatment and resection of rectal cancer].Chirurgie (Heidelberg, Germany) · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to characterize bowel function, anorectal physiology, and health-related quality of life (HRQoL) in rectal cancer patients following low anterior resection (LAR), comparing three groups: a control group with late stoma closure (LSC) (> 3 months), an early stoma closure group (ESC) (8-10 days), and an anastomotic leakage group (AL).
methodsThis cross-sectional study evaluated anorectal function using anorectal manometry. Bowel function and HRQoL were assessed using the low anterior resection syndrome (LARS) score and the EORTC QLQ-CR29 questionnaires.
resultsOf 124 eligible participants, 42 accepted participation. ESC and AL had significantly lower median (IQR) pressures in mmHg compared to LSC: rest: LSC: 54 (50-77), ESC: 35 (20-45), AL: 28 (22.5-33), p = 0.001, p < 0.001; squeeze: LSC: 140 (95-168), ESC: 70 (46-95), AL: 71 (45-81.5), p = 0.010, p = 0.004; squeeze pressure increments: LSC: 72 (60-89), ESC: 36 (30-48) and AL: 38 (25.5-54), p = 0.003, p = 0.004. ESC showed higher but non-significant median (IQR) volumes in ml: first sensation: LSC: 30 (20-40), ESC: 40 (30-50), p = 0.153; urge: LSC: 55 (45-100), ESC: 90 (65-100) p = 0.269; max: LSC: 110 (80-180), ESC: 142 (105-179), p = 0.713. No differences in mean (95% CI) total LARS scores were detected: LSC: 26.5 (21.9-31.1), ESC: 29.5 (25.9-33.1), AL: 33.0 (28.0-38.0), p = 0.320, p = 0.051. Mean (95% CI) stool frequency was significantly higher in AL: 44.4 (32.1-56.8) compared to LSC: 29.4 (20.5-38.4), p = 0.041. No differences in HRQoL were detected between the groups (p = 0.681, p = 0.129).
conclusionNo differences in anorectal function and HRQoL were detected between early and late reversal of diverting loop ileostomy.
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