Evidence map›Paper›PMID 41526467›Full record

ArticleSurgical endoscopy2026

Long-term outcomes of laparoscopic cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: comparable with the open approach for limited colorectal peritoneal metastases (KNUCRC-25CR1).

Soo Yeun Park, Sang Gyu Kwak, Jun Seok Park, Hye Jin Kim, Seung Ho Song, Su Jin Kang, Jong Gwang Kim, Jin Ho Baek, Byung Woog Kang, Gyu-Seog Choi

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Soo Yeun ParkColorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-Gu, Daegu, 41404, South Korea.
Sang Gyu KwakDepartment of Medical Statistics, School of Medicine, Daegu Catholic University, Daegu, South Korea.
Jun Seok ParkColorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-Gu, Daegu, 41404, South Korea.
Hye Jin KimColorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-Gu, Daegu, 41404, South Korea.
Seung Ho SongColorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-Gu, Daegu, 41404, South Korea.
Su Jin KangColorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-Gu, Daegu, 41404, South Korea.
Jong Gwang KimDepartment of Oncology/Hematology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jin Ho BaekDepartment of Oncology/Hematology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Byung Woog KangDepartment of Oncology/Hematology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Gyu-Seog ChoiColorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, 807 Hogukro, Buk-Gu, Daegu, 41404, South Korea. kyuschoi@knu.ac.kr.ORCID http://orcid.org/0000-0001-5476-4610

Funding

Korean government (MSIT) 2021R1A2C1005342
6 · The paper itself

Abstract

backgroundSome patients with early-stage colorectal peritoneal metastasis require cytoreductive surgery (CRS) to a limited extent. This study aimed to evaluate the long-term outcomes of laparoscopic versus open surgery for limited peritoneal metastases, including survival outcomes and progression patterns.

methodsThis retrospective study analyzed data from 68 patients who underwent CRS and hyperthermic intraperitoneal chemotherapy (HIPEC) at a single university hospital between January 2014 and December 2021. Postoperative and survival outcomes were compared between the laparoscopic CRS (L-CRS) and open CRS (O-CRS) groups before and after propensity-score (PS) matching. Primary outcomes were overall survival (OS), progression-free survival (PFS), and peritoneal PFS (P-PFS).

resultsOf the 68 patients, 42 underwent L-CRS, and 26 underwent O-CRS. After PS matching, preoperative characteristics of the patients were well balanced. Postoperative complications were not different between the two groups. The length of hospital stay was significantly shorter in the L-CRS group than in the O-CRS group. The median OS was 37.3 (95% confidence interval [CI] 15.6-59.0) months in the L-CRS group and 34.1 (95% CI 1.9-66.4) months in the O-CRS group (p = 0.535). PFS and P-PFS were not significantly different between the two groups. Multivariate analysis revealed that extraperitoneal metastasis status was the only significant factor associated with OS and PFS. Progression patterns were not different between the two groups.

conclusionsL-CRS and HIPEC could achieve comparable oncologic outcomes to open surgery in highly selected patients with limited peritoneal metastases from colorectal cancer.

Indexed as

Colorectal NeoplasmsCytoreduction Surgical ProceduresHyperthermic Intraperitoneal ChemotherapyLaparoscopyPeritoneal NeoplasmsAdultAgedCombined Modality TherapyFemaleHumansLength of StayMaleMiddle AgedRetrospective StudiesTreatment OutcomeColorectal neoplasmCytoreductionHyperthermic intraperitoneal chemotherapyLaparoscopy

Identifiers

PMID41526467
PMCPMC12971802

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.