ArticleInternational journal of obesity (2005)2026
Metabolic remodeling and the modulatory role of vitamin D deficiency in African American children and adolescents with obesity.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
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5 authors.
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Abstract
backgroundObesity is a complex metabolic condition with a disproportionate impact among African American youth. Metabolomic profiling enables high-resolution mapping of obesity-related biochemical changes across metabolic pathways.
methodsWe analyzed 551 African American pediatric participants (aged 2-21 years) recruited at the Children's Hospital of Philadelphia between 2002 and 2020. Vitamin D deficiency was observed in 86 participants, including 62 of 309 individuals with overweight or obesity (20%). Plasma metabolites were quantified using the Nightingale NMR platform. Obesity was defined using age- and sex-specific BMI percentiles.
resultsA total of 142 individual metabolite markers and ratios were significantly associated with obesity (FDR < 0.05). Obesity‑related metabolic changes were characterized by elevated branched-chain and aromatic amino acids, GlycA, and triglyceride-rich VLDL subclasses, along with reduced Gly, large HDL particles, and cholesterol-enriched lipoproteins. Global enrichment analysis identified a significant overrepresentation of nominally significant interactions with vitamin D deficiency (p < 2.2 × 10
conclusionsObesity in African American youth is linked to widespread metabolic remodeling across amino acid, lipid, and inflammatory pathways, reflecting core features of cardiometabolic risk. Vitamin D status may also influence these responses, suggesting a potential role in modifying obesity-related risk. These findings highlight the importance of early identification and prevention strategies and point to vitamin D as a possible target for future investigation.
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