Evidence map›Paper›PMID 41526448›Full record

ArticleScientific reports2026

Air-fed cold atmospheric plasma device as a safe and effective anti-SARS-CoV-2 air filter.

Fei Cao, An Yan, Qingnan Xu, Qiujie Fang, Xiao Chen, Shuang Xue, Longfei Qie, Jie Fang, Gbenga A Martins, Ye Lu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fei Cao *Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. f.cao@siat.ac.cn.
An Yan *College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Qingnan XuPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Qiujie FangPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xiao ChenPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Shuang XueCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Longfei QieCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Jie FangZhejiang Provincial Laboratory of Experimental Animals & Nonclinical Laboratory Studies, Hangzhou Medical College, Hangzhou, 310059, China.
Gbenga A MartinsPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Ye LuDepartment of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, China.
Jamoliddin RazzokovInstitute of Fundamental and Applied Research, National Research University TIIAME, Kori Niyoziy 39, Tashkent, 100000, Uzbekistan.
Ruixue WangCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Guiqiang WangDepartment of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, 100034, China. john131212@126.com.
Zhitong ChenPaul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Funding

Beijing Natural Science Foundation JQ23013Beijing Nova Program 2022015,20230484449National Key Research and Development Program of China 2022YFE0126000National Key Research and Development Program of China 2025YFE0114500Shenzhen Medical Academy of Research and Translation C2301011Shenzhen Science and Technology Major Project KJZD20230923114406014the Fundamental Research Funds for the Central Universities buctrc201906the Guangdong Basic and Applied Basic Research Foundation 2022A1515011129the National Natural Science Foundation of China - Young Scientist Fund 52407188
6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) displays antiviral properties, and its efficacy and safety in daily use are subject to full elucidation. In this work, we develop an air-fed CAP device, by inhaling and filtering, to directly inactivate SARS-CoV-2 in the air. The plasma shows a high intensity with reactive nitrogen and oxygen species in optical emission, with plasma electron temperature and density of 0.31 eV and 3.25 × 1017 m-3, respectively, confirming a strong discharge for SARS-CoV-2 disinfection. A qualitative analysis of the device’s discharge process is conducted using a two-dimensional fluid model. The disinfection results show that the typical SARS-CoV-2 morphological spikes disappear after plasma treatment, and the proteosomes of the SARS-CoV-2 virus change. In addition, we conduct experiments on rats to evaluate the safety of the air plasma device in daily use. Rats’ behavior, body weight, food consumption, organ histopathology, and blood biochemical indicators after exposure to this device are evaluated. These results demonstrate that under our experimental conditions, this prototype plasma–air circulation system altered the structural integrity of SARS-CoV-2 and did not produce overt acute toxicity in rats over 4 weeks, although some serum chemistry parameters changed and require further evaluation.

Indexed as

Cold atmospheric plasmaElectron densityMorphological spikesSafety evaluationSARS-CoV-2 disinfection

Identifiers

PMID41526448
PMCPMC12876883

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.