Novel ten second antimicrobial coating for endotracheal tubes to prevent ventilator associated pneumonia.

Manar Fathy Al-Sayed, Mohamed Tarek El-Wakad, Mohammed A Hassan, Ahmed M Soliman, Amal S Eldesoky

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manar Fathy Al-SayedBiomedical Engineering Department Faculty of Engineering , Helwan University , Cairo, Egypt.

Mohamed Tarek El-WakadBiomedical Engineering Department , Future University in Egypt , Cairo, Egypt. mohamed.elwakad@fue.edu.eg.

Mohammed A HassanBiomedical Engineering Department Faculty of Engineering , Helwan University , Cairo, Egypt.

Ahmed M SolimanBiomedical Engineering Department Faculty of Engineering , Helwan University , Cairo, Egypt.

Amal S EldesokyBiomedical Engineering Department , Higher Technological Institute 10th of Ramadan , Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This novel approach aims to mitigate ventilator-associated pneumonia (VAP) in critically ill patients by improving the coating of endotracheal tubes (ETT). The research focuses on creating durable, antimicrobial coatings to prevent bacterial colonization on endotracheal tube surfaces. Using a 10-second exposure to solvents such as dimethylformamide (DMF) and tetrahydrofuran (THF), the study successfully demonstrated a robust coating on polyvinyl chloride (PVC) tubing. This coating inhibits the growth of Escherichia coli while maintaining biocompatibility and avoiding the toxic effects of traditional silver nitrate coatings. Quantitatively, the coatings achieved pH values of 5-5.5, viscosities of 0.6-1 mPa·s, and reduced microbial counts to 4 CFU/µL, compared to 5 CFU/µL in the controls. Biocompatibility remained high, with cell viability exceeding 98% for DMF and THF coatings. The research highlights a significant advance in combating ventilator-associated pneumonia, although clinical trials are needed to validate these promising results for clinical applications in intensive care settings.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsCoated Materials, BiocompatibleIntubation, IntratrachealPneumonia, Ventilator-AssociatedDimethylformamideEscherichia coliFuransHumansPolyvinyl ChlorideAnti-Bacterial AgentsAnti-Infective AgentsCoated Materials, BiocompatibleDimethylformamideFuransPolyvinyl ChloridetetrahydrofuranAntimicrobial coatingBacterial colonizationBiocompatibilityCritical careDimethylformamideEndotracheal tubeEscherichia coli (E. coli)Insta-coatingPolyvinyl chlorideTetrahydrofuranVentilator-associated pneumonia

Identifiers

PMID41526447

DOI10.1038/s41598-025-31706-7

PMCPMC12800253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.