Evidence map›Paper›PMID 41526440›Full record

ArticleScientific reports2026

A validation of 3D imaging for non-invasive, tech-assisted diagnosis of caries and erosive tooth wear in primary teeth - an in vitro study.

Astrid Carolina Valdivia-Tapia, Graham Haines, Bala Sankuratri, Iqra Walayat, Peter Frank Castelluccio, Anderson Takeo Hara, Aline Castilho

Abstract readValidation Study
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Astrid Carolina Valdivia-TapiaDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, USA.
Graham HainesPredoctoral Students, Indiana University School of Dentistry, Indianapolis, USA.
Bala SankuratriPredoctoral Students, Indiana University School of Dentistry, Indianapolis, USA.
Iqra WalayatPredoctoral Students, Indiana University School of Dentistry, Indianapolis, USA.
Peter Frank CastelluccioDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, USA.
Anderson Takeo HaraDepartment of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, USA.
Aline CastilhoDepartment of Pediatric Dentistry, Indiana University School of Dentistry, 1121 W Michigan St, Room 220H, Indianapolis, IN, 46202, USA. alifrei@iu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This in vitro study set out to assess the agreement of 3D-colored digital dental images in detecting occlusal caries and erosive tooth wear (ETW) in primary teeth, by comparing indirect digital assessments with conventional direct visual examinations. Extracted primary molars with varying degrees of caries severity and ETW were mounted on modeling wax, with the crowns exposed for the assessments. Then, two independent experiments were conducted. The first analyzed occlusal caries in 233 extracted primary molars using the International Caries Detection and Assessment System (ICDAS, scores 0-6), while the second evaluated ETW in 164 primary molars using the Basic Erosive Wear Examination (BEWE, scores 0-3). Direct visual examinations were performed under standardized lighting, dryness and magnification. For the indirect assessment, teeth were scanned using an intraoral scanner (TRIOS 4, 3Shape), and digital images were assessed via 3Shape Unite software. Agreement between methods was determined using kappa statistics and percent agreement. Substantial agreement was found for caries detection (Kappa = 0.64; 71% agreement) with the highest concordance at ICDAS scores 4-6 (> 90%) and the lowest at score 0 (36%). For ETW, substantial agreement was also observed Kappa = 0.58; 80% agreement), with highest concordance at BEWE score 2 (99%). The digital method tended to overestimate scores 0 and 1 and underestimate scores 2 and 3 in caries detection. 3D-colored digital images demonstrated substantial agreement with conventional visual methods for detecting both dental caries and ETW in primary teeth. These results highlight its promise as a practical and non-invasive adjunct in pediatric dental diagnostics, with potential to enhance early detection and support the integration of digital tools into routine and remote oral health care.

Indexed as

Dental CariesImaging, Three-DimensionalTooth, DeciduousTooth ErosionTooth WearHumansMolar3D imageCaries detectionDigital dentistryErosive tooth wearPrimary teeth

Identifiers

PMID41526440
PMCPMC12877137

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.