Evidence map›Paper›PMID 41526424›Full record

ArticleScientific reports2026

Estimating covariate-balanced survival curve in distributed data environment using data collaboration quasi-experiment.

Akihiro Toyoda, Yuji Kawamata, Tomoru Nakayama, Akira Imakura, Tetsuya Sakurai, Yukihiko Okada

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akihiro ToyodaGraduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0009-0008-0427-2587
Yuji KawamataCenter for Artificial Intelligence Research, Tsukuba Institute for Advanced Research, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan. yjkawamata@gmail.com.ORCID http://orcid.org/0000-0003-3951-639X
Tomoru NakayamaGraduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan.
Akira ImakuraCenter for Artificial Intelligence Research, Tsukuba Institute for Advanced Research, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan.ORCID http://orcid.org/0000-0003-4994-2499
Tetsuya SakuraiCenter for Artificial Intelligence Research, Tsukuba Institute for Advanced Research, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan.ORCID http://orcid.org/0000-0002-5789-7547
Yukihiko OkadaCenter for Artificial Intelligence Research, Tsukuba Institute for Advanced Research, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8573, Japan.ORCID http://orcid.org/0000-0003-4903-4191

Funding

Japan Science and Technology Agency JPMJPF2017Japan Science and Technology Agency JPMJSP2124Japan Society for the Promotion of Science JP22K19767Japan Society for the Promotion of Science JP23K22166
6 · The paper itself

Abstract

The sharing of patient-level data necessary for covariate-adjusted survival analysis between medical institutions is difficult due to privacy protection restrictions. We propose a privacy-preserving framework that estimates balanced Kaplan-Meier curves from distributed observational data without exchanging raw data. Each institution sends only the low-dimensional representation obtained through dimensionality reduction of the covariate matrix. Analysts reconstruct the aggregated dataset, perform propensity score matching, and estimate survival curves. Experiments using simulation datasets and five publicly available medical datasets showed that the proposed method consistently outperformed single-site analyses. This method can handle both horizontal and vertical data distribution scenarios and enables the collaborative acquisition of reliable survival curves with minimal communication and no disclosure of raw data.

Indexed as

Survival AnalysisAlgorithmsComputer SimulationHumansKaplan-Meier EstimatePropensity ScoreCovariate adjustmentData collaborationPrivacy-preserving survival analysisPropensity score matchingSurvival curve

Identifiers

PMID41526424
PMCPMC12835124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.