ReviewNature communications2026
Propellane-free access to bicyclo[1.1.1]pentanes.
Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond para- and meta-Substitution: Synthesis and Biological Validation of Chalcogen-Rich Thiabicyclo[3.1.1]heptanes as Bioisosteres of Aryl Thioether Derivatives.Angewandte Chemie (International ed. in English) · 2026Article
- Asymmetric Deoxy-Fluoroalkylation of Amides Enabled by Transimination.Organic letters · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Bicyclo[1.1.1]pentane (BCP) has emerged over the past decade as a valuable three-dimensional bioisostere for benzene, attracting considerable interest in pharmaceutical research for its ability to improve drug-like properties. Although [1.1.1]propellane has traditionally served as the key precursor to mono- and 1,3- disubstituted BCPs, the growing demand for multisubstituted and bridge-functionalized BCP derivatives has spurred the development of alternative, propellane-free synthetic strategies. Recent advances toward these highly strained and sterically hindered ring systems can be broadly organized into three mechanistic categories: intramolecular diradical couplings, carbene-mediated ring expansions, and two-electron disconnections. This Perspective highlights these emerging methodologies, assesses their scope and limitations, and offers an outlook on remaining synthetic challenges and their implications for medicinal chemistry.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.