Evidence map›Paper›PMID 41526341›Full record

ArticleNature communications2026

RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b

Chi Yan, Weifeng Luo, Jinming Yang, Jing Yang, Sheau-Chiann Chen, Kensey Bergdorf, Qianni Hu, Vivian L Weiss, Douglas B Johnson, Qi Liu and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Photodynamic therapy modulates proliferation in carcinoma and melanoma: from clonogenic survival to tumor development.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chi YanDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. chi.yan@umanitoba.ca.ORCID http://orcid.org/0000-0002-8658-7302
Weifeng LuoDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Jinming YangDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Jing YangDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Sheau-Chiann ChenDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Kensey BergdorfDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Qianni HuDivision of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Vivian L WeissDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0874-3207
Douglas B JohnsonDivision of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6390-773X
Qi LiuDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-8892-7078
Ann RichmondDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA. ann.richmond@vanderbilt.edu.ORCID http://orcid.org/0000-0002-9580-900X

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Targeting the NF-kappaB Pathway in MelanomaR01CA116021 · NCI · VANDERBILT UNIVERSITY · PI RICHMOND, ANN, YAN, CHI · 2005 to 2024
$6.7M
The Role of Cancer-Associated Fibroblasts in Thyroid CarcinomaR01CA272875 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEISS, VIVIAN LEE · 2022 to 2025
$2.5M
The role of Wnt signaling in aggressive thyroid carcinomaK08CA240901 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WEISS, VIVIAN LEE · 2020 to 2024
$1.1M
Leica Bond RXS10OD023475 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOYD, KELLI L. · 2018 to 2018
$213k
BLRD VA I01 BX002301BLRD VA IK6 BX005225NCI NIH HHS K08 CA240901NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA116021NCI NIH HHS R01 CA272875NIDDK NIH HHS P30 DK058404NIH HHS S10 OD023475
6 · The paper itself

Abstract

Development of effective second-line treatment options for patients with BRAF

Indexed as

CD40 AntigensMelanomaProgrammed Cell Death 1 ReceptorAnimalsCD11b AntigenCell Line, TumorDrug Resistance, NeoplasmFemaleHumansImmune Checkpoint InhibitorsMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafPyridonesPyrimidinonesCD11b AntigenCD40 AntigensImmune Checkpoint InhibitorsPhosphatidylinositol 3-KinasesProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins B-rafPyridonesPyrimidinonesras Proteinstrametinib

Identifiers

PMID41526341
PMCPMC12796310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.