Evidence map›Paper›PMID 41526269›Full record

ArticleThe Journal of veterinary medical science2026

Distribution of domestic cat hepatitis B virus in cholangiocarcinoma and non-neoplastic liver tissue.

Haruka Dosaka, Nanami X Kato, Kei Taga, Soshin Yamamoto, Kaito Kondo, Rissar Siringo Ringo, Yasuyuki Kaneko, Takuya Hirai, Akatsuki Saito, Naoyuki Fuke

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haruka DosakaDepartment of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Nanami X KatoLaboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Kei TagaTokyo Cat Specialists, Tokyo, Japan.
Soshin YamamotoTokyo Cat Specialists, Tokyo, Japan.
Kaito KondoDepartment of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Rissar Siringo RingoLaboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Yasuyuki KanekoVeterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Takuya HiraiDepartment of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Akatsuki SaitoLaboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Naoyuki FukeDepartment of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Domestic cat hepatitis B virus (DCHBV), shares similarities with human hepatitis B virus (HBV) which is associated with liver disease. We report the first case of cholangiocarcinoma in a 17-year-old spayed female cat infected with DCHBV and positive for feline immunodeficiency virus. The patient presented with vomiting, anorexia, and an elevated globulin level. Ultrasonography revealed multiple hypoechoic hepatic lesions, and histopathology confirmed cholangiocarcinoma. The tumor exhibited CK7 positivity and HepPar-1 negativity, confirming biliary origin. Quantitative PCR detected DCHBV in the spleen and ascitic fluid, while immunohistochemistry and RNA in situ hybridization revealed viral antigen and mRNA in both tumor and non-tumor liver. The presence of a viral antigen and mRNA in neoplastic tissue suggests a potential role for DCHBV in hepatobiliary carcinogenesis.

Indexed as

Bile Duct NeoplasmsCat DiseasesCholangiocarcinomaHepatitis B virusLiverAnimalsCatsFemaleImmunodeficiency Virus, Felinecatcholangiocarcinomadomestic cat hepatitis B virusimmunohistochemistryin situ hybridization

Identifiers

PMID41526269
PMCPMC13000449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.