ArticleAnnals of laboratory medicine2026
Changes in Sero-immunological Status for Infectious Diseases in Solid Organ Transplantation: A 20-Year Single-Center Study in Korea.
Article in Annals of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Evolving Sero-immunological Profiles of Solid Organ Transplant Candidates in Korea.Annals of laboratory medicine · 2026Article
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With increasing solid organ transplantations (SOTs), updated sero-immunological data are essential, as immune profiles shift across generations and influence preventive strategies. We aimed to evaluate the current sero-immunological status of SOT recipients in Korea. Methods: We retrospectively analyzed pre-transplant sero-immunological test results for 12 infectious diseases from SOT recipients and donors at a single center over 20 yrs. All serological test results obtained during pre-transplant evaluations were included; identical results from repeat tests conducted within 1 yr were excluded. Temporal trends in seropositivity were assessed based on test year, age at testing, and birth cohort. Results: In total, 51,096 pre-transplant serological test results (35,159 from recipients and 15,937 from donors) were analyzed. Seropositivity rates remained stable throughout the test year, except for a decline for tuberculosis-specific interferon-gamma release assay (TB IGRA). By birth cohort, seropositivity for varicella-zoster virus (98.8%), herpes simplex virus (HSV; 95.7%), and cytomegalovirus (CMV, 99.4%) was high in individuals born before the 1980s but declined in younger cohorts (69.3%, 46.6%, and 81.1%, respectively; all Conclusions: The sero-immunological landscape of SOT candidates has changed over time, reflecting generational shifts in Korean society. These changes highlight the importance of targeted screening and tailored management, particularly for high-risk donor-seropositive/recipient-seronegative transplantations, as well as the critical need for timely immunization in transplant candidates.
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