Evidence map›Paper›PMID 41526192›Full record

ArticleGenome research2026

Landscape of microRNA and target expression variation and covariation in single mouse embryonic stem cells.

Marcel Tarbier, Sebastian D Mackowiak, Vaishnovi Sekar, Franziska Bonath, Etka Yapar, Bastian Fromm, Omid R Faridani, Inna Biryukova, Marc R Friedländer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcel TarbierScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 114 18 Stockholm, Sweden; marcel.tarbier@scilifelab.se marc.friedlander@scilifelab.se.
Sebastian D MackowiakBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Center of Digital Health, 10178 Berlin, Germany.
Vaishnovi SekarScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 114 18 Stockholm, Sweden.
Franziska BonathScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 114 18 Stockholm, Sweden.
Etka YaparDepartment of Biology, Lund University, SE-221 00 Lund, Sweden.
Bastian FrommThe Arctic University Museum of Norway, UiT-The Arctic University of Norway, NO-9037 Tromsø, Norway.ORCID 0000-0003-0352-3037
Omid R FaridaniSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052 Australia.ORCID 0000-0001-9330-887X
Inna BiryukovaScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 114 18 Stockholm, Sweden.
Marc R FriedländerScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE 114 18 Stockholm, Sweden; marcel.tarbier@scilifelab.se marc.friedlander@scilifelab.se.ORCID 0000-0001-6577-4363

Funding

European Research Council 758397
6 · The paper itself

Abstract

microRNAs are small RNA molecules that can repress the expression of protein-coding genes post-transcriptionally. Previous studies have shown that microRNAs can also have alternative functions, including influencing target expression variation and covariation, but these observations have been limited to a few microRNAs. Here we systematically study microRNA alternative functions in mouse embryonic stem cells (mESCs) by genetically deleting

Indexed as

MicroRNAsMouse Embryonic Stem CellsAnimalsGene Expression RegulationMiceRibonuclease IIISingle-Cell AnalysisSingle-Cell Gene Expression AnalysisDrosha protein, mouseMicroRNAsMirn182 microRNA, mouseMIRN290 microRNA, mouseRibonuclease III

Identifiers

PMID41526192
PMCPMC12863184

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.