ArticleGenes & development2026
Independent control of neurogenesis and dorsoventral patterning by NKX2-2.
Sumin Jang, Elena V Abarinov, Julie A Dobkin, Erica C Hurley, Michael Closser, Lori Sussel, Hynek Wichterle
Abstract read
In one paragraphArticle in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Sumin JangDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA; suminjang@gmail.com hw350@columbia.edu.ORCID 0000-0001-8918-7059 Elena V AbarinovDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Julie A DobkinDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Erica C HurleyDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Michael ClosserDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA.
Lori SusselBarbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.ORCID 0000-0003-4672-7304 Hynek WichterleDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York 10032, USA; suminjang@gmail.com hw350@columbia.edu.
Funding
Regulation of Pancreatic Islet Cell FateR01DK082590 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2009 to 2026
$7.3MTranscriptional Control of Motor Neuron MaturationR01NS116141 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WICHTERLE, HYNEK · 2020 to 2024
$1.9MRNA regulatory networks in motor neuron development and functionR01NS089676 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHANG, CHAOLIN · 2015 to 2019
$1.8MIdentifying human-specific neural progenitors and their role in neurodevelopmentR00MH130892 · NIMH · UNIVERSITY OF CHICAGO · PI Sumin Jang · 2025 to 2026
$448kIdentifying human-specific neural progenitors and their role in neurodevelopmentK99MH130892 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JANG, SUMIN · 2023 to 2024
$272kNIDDK NIH HHS R01 DK082590NIMH NIH HHS K99 MH130892NIMH NIH HHS R00 MH130892NINDS NIH HHS R01 NS089676NINDS NIH HHS R01 NS116141
6 · The paper itselfAbstract
Human neurogenesis is disproportionately protracted, lasting >10 times longer than in mice, allowing neural progenitors to undergo more rounds of self-renewing cell divisions and generate larger neuronal populations. In the human spinal cord, expansion of the motor neuron lineage is achieved through a newly evolved progenitor domain called the ventral motor neuron progenitor (vpMN) that delays and expands motor neurogenesis. This behavior of vpMNs is controlled by transcription factor NKX2-2, which in vpMNs is coexpressed with classical motor neuron progenitor (pMN) marker OLIG2. In this study, we sought to determine the molecular basis of NKX2-2-mediated extension and expansion of motor neurogenesis. We found that, unlike in mice or chicks, NKX2-2 in the human spinal cord does not repress dorsoventral patterning genes like
Indexed as
Body PatterningGene Expression Regulation, DevelopmentalHomeodomain ProteinsNeurogenesisTranscription FactorsAnimalsBasic Helix-Loop-Helix ProteinsHomeobox Protein Nkx-2.2HumansMiceMotor NeuronsNerve Tissue ProteinsNeural Stem CellsNuclear ProteinsOligodendrocyte Transcription Factor 2Spinal CordBasic Helix-Loop-Helix ProteinsHomeobox Protein Nkx-2.2Homeodomain ProteinsNerve Tissue Proteinsnkx2.2b protein, zebrafishNKX2-2 protein, humanNkx2-2 protein, mouseNuclear ProteinsOligodendrocyte Transcription Factor 2Transcription FactorsZebrafish Proteinshuman neurodevelopmentmotor neurogenesisneurogenesis timingNKX2-2
Identifiers
PMID41526180
PMCPMC12951754
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