ArticleJournal of the American Chemical Society2026
Fluorescence Transduction of Liquid Crystal Ordering Transitions for Biosensing.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Stepwise Conformational Restriction of Acylhydrazone-Based Molecules for High Signal-to-Noise Fluorescent Recognition of Synthetic Cannabinoid FUB-INACA.Angewandte Chemie (International ed. in English) · 2026Article
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2 authors.
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Abstract
Liquid crystal (LC) ordering transitions are exquisitely sensitive to molecular interactions at aqueous interfaces and have long served as the basis for optical biosensors. However, the readout of these transitions has almost exclusively relied on polarized-light optical microscopy, which limits quantification and hinders practical deployment. Here, we report a fluorescence-based transduction scheme that converts LC ordering transitions to quantitative optical outputs. Our strategy employs amphiphilic block copolymers bearing aggregation-induced emission (AIE) motifs that undergo dynamic covalent conjugation with IgG antibodies through reversible imine chemistry. In complex LC emulsions, polymer surfactants localize differently depending on droplet LC configuration: accumulation at monopolar defects concentrates AIE units to generate a bright ON state, whereas redistribution along the LC/water interface in the radial configuration suppresses emission to yield an OFF state. Recognition of
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