ArticlePLoS neglected tropical diseases2026
Evaluating the impact of nitisinone at mosquito-lethal doses on Lutzomyia longipalpis.
Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comment on: Evaluating the impact of nitisinone at mosquito-lethal doses on Lutzomyia longipalpis.PLoS neglected tropical diseases · 2026Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Nitisinone, a systemic inhibitor of tyrosine catabolism, has recently emerged as a promising endectocide with demonstrated lethality against mosquitoes and tsetse flies. To assess its efficacy against Lutzomyia longipalpis, an important vector of Leishmania infantum -the causative agent of zoonotic visceral leishmaniasis prevalent in the Mediterranean basin, Latin America, and parts of the Middle East-, we exposed sand flies to a concentration previously shown to be lethal to Anopheles mosquitoes (250 ng/mL). Survival was monitored over 14 days and showed no significant difference between treated and control groups, indicating a lack of insecticidal effect at this dose. These findings suggest that Lu. longipalpis exhibits tolerance to nitisinone, likely due to species-specific metabolic differences. Although nitisinone remains a promising tool for systemic vector control, its effectiveness against sand flies may require higher doses or alternative compounds.
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