Evidence map›Paper›PMID 41525303›Full record

ReviewDigestion2026

Gastric Epithelial Neoplasms in <italic>Helicobacter pylori</italic>-Uninfected Patients.

Hiroya Ueyama, Takashi Yao, Shunsuke Nakamura, Yasuko Uemura, Tomoyo Iwano, Momoko Yamamoto, Daiki Abe, Shotaro Oki, Tsutomu Takeda, Yoichi Akazawa and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Digestion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroya UeyamaDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan, psyro@juntendo.ac.jp.
Takashi YaoDepartment of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Shunsuke NakamuraDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Yasuko UemuraDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Tomoyo IwanoDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Momoko YamamotoDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Daiki AbeDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Shotaro OkiDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Tsutomu TakedaDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Yoichi AkazawaDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Kumiko UedaDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Mariko HojoDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.
Akihito NagaharaDepartment of Gastroenterology, Juntendo University, Faculty of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, several studies have described the clinicopathological characteristics of Helicobacter pylori (H. pylori)-uninfected gastric cancer. This entity is now recognized as one of the major topics in gastric cancer research and clinical practice. SUMMARY: Currently, H. pylori-uninfected gastric epithelial neoplasms (HpUGENs; excluding adenocarcinomas of the esophagogastric junction and gastric neuroendocrine tumors) are classified into seven subtypes in our research results: raspberry-type gastric epithelial neoplasm (GEN; foveolar-type adenoma), whitish flat elevated-type GEN (GEN with gastric phenotype), gastric adenocarcinoma of fundic gland type (GA-FG), gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM), other GEN with a gastric phenotype (complex type of GEN with gastric phenotype), GEN with an intestinal or gastrointestinal mixed phenotype arising in the pyloric gland region, and signet ring cell carcinoma. KEY MESSAGES: This study outlines our analysis of current cases, detailing the endoscopic and clinicopathological characteristics of HpUGENs, and provides practical insights for their endoscopic and pathological diagnosis. Since many of these neoplasms histologically show low-grade atypia, they are sometimes diagnosed as gastric adenoma or gastric dysplasia rather than adenocarcinoma in the World Health Organization classification, highlighting the need for standardized histopathological diagnostic criteria of GENs with low-grade atypia. Moreover, as no clinical practice guidelines have yet been established for HpUGENs, future research should aim to elucidate the relationship between early and advanced lesions, perform comprehensive analyses of H. pylori-uninfected advanced gastric cancer, and conduct molecular biological studies to achieve a better understanding of the entire disease spectrum and to establish evidence-based clinical guidelines.

Indexed as

Gastric adenocarcinoma of fundic gland mucosa typeGastric adenocarcinoma of fundic gland typeGastric cancerGastric dysplasiaGastric epithelial neoplasms of fundic gland mucosa lineageGastric neoplasms in Helicobacter pylori-naive patientsHelicobacter pyloriHelicobacter pylori-uninfected gastric epithelial neoplasmsMucin phenotypeSignet ring cell carcinoma

Identifiers

PMID41525303
PMCPMC12999187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.