Evidence map›Paper›PMID 41525254›Full record

ArticleJournal of agricultural and food chemistry2026

Proteomics Analysis of Celiac Disease-Active Peptides in Food Products with Partially Hydrolyzed Gluten.

Eleonora Tissen, Lana Dakwar, Sabrina Geisslitz, Katharina Anne Scherf

Abstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eleonora TissenTUM School of Life Sciences, Professorship of Food Biopolymer Systems, Technical University of Munich, Lise-Meitner-Str. 34, Freising 85354, Germany.ORCID 0009-0005-0943-5101
Lana DakwarTUM School of Life Sciences, Professorship of Food Biopolymer Systems, Technical University of Munich, Lise-Meitner-Str. 34, Freising 85354, Germany.
Sabrina GeisslitzLeibniz Institute for Food Systems Biology at the Technical University of Munich, Lise-Meitner-Str. 34, Freising 85354, Germany.ORCID 0000-0002-6811-4069
Katharina Anne ScherfTUM School of Life Sciences, Professorship of Food Biopolymer Systems, Technical University of Munich, Lise-Meitner-Str. 34, Freising 85354, Germany.ORCID 0000-0001-8315-5400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foods with partially hydrolyzed gluten may still trigger immune responses in celiac disease (CeD) patients due to residual CeD-active peptides. We applied nanoliquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) to identify 54 CeD-active peptides in 15 barley malt extracts (BME), seven barley malt vinegars (BMV), and 15 soy sauces. Eight common CeD-active peptides were quantitated with targeted nanoLC-MS/MS and stable isotope dilution assay. Total peptide concentrations ranged from 481 mg/kg to 1305 mg/kg in BMEs, whereas three samples showed peptide concentrations near LOQ. Six BMVs had peptide concentrations of up to 0.04 mg/kg, and in soy sauce, they ranged from 0.2 mg/kg to 0.5 mg/kg. Peptide concentrations correlated with gluten content measured by R5c ELISA in BMEs and BMV, while soy sauce showed a gluten content below the LOQ by ELISA. These findings show the presence of CeD-active peptides in foods containing partially hydrolyzed gluten, highlighting the need for comprehensive risk assessment.

Indexed as

Celiac DiseaseGlutensHordeumPeptidesHumansHydrolysisProteomicsTandem Mass SpectrometryGlutensPeptidesbarley malt extractbarley malt vinegarimmunogenic epitopesnanoLC-MS/MSsoy saucestable isotope dilution assay

Identifiers

PMID41525254
PMCPMC12862762

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.