Evidence map›Paper›PMID 41524977›Full record

ArticleCardiovascular toxicology2026

Cardiometabolic Dysregulation and PON1 Genetic Susceptibility in Chronic E-waste Recyclers Exposed to Potentially Toxic Elements.

Aneela Shoukat, Syed Muhammad Nurulain, Rashid Nazir Qureshi, Amina Zafar, Sabir Hussain, Sosan Andleeb Khan, Sajid Mehmood, Sadia Asmat, Saqlain Raza, Syed Tahir Abbas Shah

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Article in Cardiovascular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Aneela ShoukatDepartment of Allied Health Sciences, Iqra University, Chak Shahzad Campus, Islamabad, Pakistan.
Syed Muhammad NurulainDepartment of Biosciences, Grand Asian University, Sialkot, Pakistan. syednurulain@gaus.edu.pk.
Rashid Nazir QureshiCentral Analytical Facility Division, Institute of Nuclear Science and Technology (PINSTECH), Islamabad, Pakistan.
Amina ZafarCentral Analytical Facility Division, Institute of Nuclear Science and Technology (PINSTECH), Islamabad, Pakistan.
Sabir HussainDepartment of Biosciences, COMSATS University Islamabad, Islamabad Campus, Park Road, Tarlai, Islamabad, 45550, Pakistan.
Sosan Andleeb KhanDepartment of Biotechnology, University of Poonch, Rawalakot, Pakistan.
Sajid MehmoodDepartment of Biosciences, Grand Asian University, Sialkot, Pakistan.
Sadia AsmatDepartment of Biosciences, Grand Asian University, Sialkot, Pakistan.
Saqlain RazaRespiratory Care Department, College of Applied Medical Science in Jubail, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia.
Syed Tahir Abbas ShahDepartment of Biosciences, COMSATS University Islamabad, Islamabad Campus, Park Road, Tarlai, Islamabad, 45550, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electronic waste (e-waste) is the world’s fastest-growing category of hazardous solid waste and poses a serious health risk. In this study, we investigated heavy metals, a significant component of e-waste, and biochemicals, including Paraoxonase 1 (PON1) activity, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), among chronic e-waste-exposed and non-exposed human individuals. We examined the PON1 gene’s single-nucleotide polymorphism (SNP) association with exposure. We conducted a cross-sectional study that included 256 adult male e-waste recyclers and 145 randomly selected non-exposed control subjects. Dust samples from e-waste areas were also analyzed for potentially toxic elements (PTEs). The Inductively coupled plasma mass spectrometry (ICP-MS) technique was employed for metal detection. The enzymatic and colorimetric approaches were used to measure biochemical parameters. The Tetra arm PCR procedure was used for SNP analysis. Mendelian randomization (MR) weighted median regression was applied to determine the association. The results revealed that all the PTEs were significantly higher in the e-waste exposed group. Except for PON1, all the biochemical parameters investigated surged while PON1 decreased in the exposed group. Zinc (Zn), mercury (Hg), lead (Pb), and cadmium (Cd) were negatively correlated with PON1, TC, HDL, and LDL, while they positively correlated with TG. This negative correlation with PON1 was more prevalent for e-waste-exposed workers who carry the GG allele (rs662). The study concludes that chronic e-waste exposure dysregulates the PON1 level and cardiac parameters, posing serious cardiovascular health risks in e-waste recyclers.

Indexed as

AryldialkylphosphataseElectronic WasteMetals, HeavyOccupational ExposurePolymorphism, Single NucleotideRecyclingAdultBiomarkersCardiometabolic Risk FactorsCase-Control StudiesCross-Sectional StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHumansLipidsMaleAryldialkylphosphataseBiomarkersLipidsMetals, HeavyPON1 protein, humanDismantlerElectronic wasteGenotypeHeavy metalsPON1RepairerToxicity

Identifiers

PMID41524977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.