Evidence map›Paper›PMID 41524931›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Predictors of mediastinitis in deep neck space infections - ten-year experience from tertiary referral center.

Jakovljevic Sasa, Arsovic Nenad, Cvorovic Ljiljana, Pavlovic Bojan, Radivojevic Nemanja, Jotic Ana, Folic Miljan, Jovanovic Katarina, Mladenovic Neda, Dragisic Milan

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Jakovljevic SasaFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-5410-3078
Arsovic NenadFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-5277-5746
Cvorovic LjiljanaFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0003-3783-1708
Pavlovic BojanFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-9191-7719
Radivojevic NemanjaFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-5117-7904
Jotic AnaFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-9862-592X
Folic MiljanFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-6049-0342
Jovanovic KatarinaFaculty of Medicine, University of Belgrade, Belgrade, Serbia. jovanovickatarina323@gmail.com.ORCID http://orcid.org/0000-0002-3649-0705
Mladenovic NedaFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0009-0001-6627-8836
Dragisic MilanFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0009-0005-3153-0543

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aimed to identify causes of deep neck space infections and factors leading to severe complications and delayed healing. We also evaluated the LRINEC, NLR, and LRINEC x NLR indicators for predicting mediastinitis. To our knowledge, this is the first study to use LRINEC and LRINEC x NLR scores for mediastinitis prediction.

methodsThis retrospective study included 118 patients treated at our institution from January 1, 2014, to December 31, 2023, with phlegmon and infections of the deep neck spaces.

resultsPatients with mediastinitis exhibited significantly elevated LRINEC, NLR, and LRINEC x NLR scores. Fatal outcomes were associated with higher levels of LRINEC x NLR, CRP, and creatinine. ROC analysis determined cutoff values for these markers: LRINEC x NLR (AUC: 0.923, cutoff: 113.01, sensitivity: 86%, specificity: 85%), NLR (AUC: 0.872, cutoff: 19.0, sensitivity: 81%, specificity: 77%), and LRINEC (AUC: 0.832, cutoff: 5.5, sensitivity: 81%, specificity: 69%).

conclusionMediastinitis, as a complication of deep neck space infections, is not rare in these patients and significantly impacts prognosis. Based on our results, we believe that the LRINEC, NLR, and LRINEC x NLR scores can serve as predictive markers for the early assessment of these patients’ conditions and the potential development of mediastinitis.

Indexed as

CellulitisMediastinitisNeckAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesROC CurveTertiary Care CentersDeep neck infectionLRINEC scoreMediastinitisPhlegmon

Identifiers

PMID41524931

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.