Evidence map›Paper›PMID 41524909›Full record

ArticleCurrent microbiology2026

Optimizing Magnesium Uptake in Lacticaseibacillus Rhamnosus To Advance Nutribiotic Strategies.

Rodica-Anita Varvara, Heike Budde, Ruth Ley, Dan Cristian Vodnar

Abstract read
In one paragraph

Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rodica-Anita VarvaraDepartment of Food Science and Technology, Life Science Institute, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur 3-5, Cluj-Napoca, 400372, Romania.
Heike BuddeDepartment of Microbiome Science, Max Planck Institute for Biology, 72076, Tübingen, Germany.
Ruth LeyDepartment of Microbiome Science, Max Planck Institute for Biology, 72076, Tübingen, Germany.
Dan Cristian VodnarDepartment of Food Science and Technology, Life Science Institute, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăștur 3-5, Cluj-Napoca, 400372, Romania. dan.vodnar@usamvcluj.ro.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium is an essential mineral involved in more than 300 enzymatic reactions, including protein synthesis, neuromuscular function, and blood pressure regulation. Recent studies have highlighted the role of probiotics, beneficial microorganisms in the human gut, in enhancing mineral absorption. However, the interaction between magnesium and probiotic strains remains poorly understood. This study aimed to investigate the capacity of Lacticaseibacillus rhamnosus ATCC 53,103 to uptake and internalize magnesium ions, using MgSO₄ as a supplementation source. The bacterium was cultivated in MRS medium with varying concentrations of MgSO₄ (0, 0.1444, 0.722, and 1.444 g/L) over seven days. Quantitative analysis revealed that at 0.722 g/L MgSO₄, intracellular magnesium accumulation peaked at 0.7 mg/dL by Day 3, representing a 7-fold increase compared to the control (0.1 mg/dL). Scanning and transmission electron microscopy indicated essential morphological changes, including ruffled cell surfaces and enhanced ribosomal visibility. These findings suggest that L. rhamnosus can internalize magnesium under enriched conditions, supporting its potential as a microbial carrier for nutribiotic applications. This work contributes to the growing field of mineral-microbe interactions and may inform the development of probiotic-based strategies to improve magnesium bioaccessibility in the human gut.

Indexed as

Lacticaseibacillus rhamnosusMagnesiumProbioticsCulture MediaHumansMagnesium SulfateCulture MediaMagnesiumMagnesium Sulfate

Identifiers

PMID41524909
PMCPMC12795921

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.