ArticleMaternal and child health journal2026
Third Generation Consequences of Small for Gestational Age Births.
Article in Maternal and child health journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo ascertain whether former small for gestational age (weight-for-gestational age < 10th percentile, SGA), compared to non-SGA, US-born women have greater SGA rates in their grandchildren.
methodsA multi-step strategy utilizing mother's date of birth and full name was used to link the vital records of Chicago-born infants (born 2005-2017) to the Illinois transgenerational birth-file of their mothers (born 1989-1991) and maternal grandmothers (born 1956-1976). These matches accounted for differing naming practices, misspellings, and typographical errors. Our population was used to define generation-one women's SGA based on sex. A population-based reference was used to define generation-three infant's SGA based on sex average birthweight. Stratified and multivariable log binomial regression analyses were performed on singleton births. The Population Attributable Risk (PAR) percentages were calculated: P
resultFormer SGA women (n = 1510) had a greater percentage of SGA births in their grandchildren than former non-SGA women (n = 9466): 23.3% versus 17.6%; RR = 1.30 (1.14, 1.52). The adjusted (controlling for daughters' selected covariates including race, education, prenatal care usage, and cigarette smoking) RR of grandchildren SGA among former SGA (compared to non-SGA) women equaled 1.22 (1.09, 1.36). The PAR of maternal grandmother's SGA status equaled 4.3% percent among African-Americans. There were too few non-Latina White women to calculate a meaningful PAR%.
conclusionsIn the US, urban women who were themselves born SGA (compared to non-SGA) have a modest increased SGA frequency in their grandchildren. A small percentage of SGA African-American births is attributable to their maternal grandmother's SGA status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.