Evidence map›Paper›PMID 41524784›Full record

ArticleMedical oncology (Northwood, London, England)2026

Adaphostin-induced oxidative stress in oesophageal neuroendocrine carcinoma: a potential therapeutic strategy.

Chelsea Penney, Ann-Katrin Piper, Jacqueline Holliday, Gary Tincknell, Simon A Joosse, Klaus Pantel, Daniel Brungs, Marie Ranson

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chelsea PenneySchool of Science, University of Wollongong, Northfields Ave, North Wollongong, NSW, Australia. cpenney@uow.edu.au.ORCID http://orcid.org/0009-0003-5066-3291
Ann-Katrin PiperSchool of Science, University of Wollongong, Northfields Ave, North Wollongong, NSW, Australia.ORCID http://orcid.org/0000-0001-5805-0084
Jacqueline HollidaySchool of Science, University of Wollongong, Northfields Ave, North Wollongong, NSW, Australia.ORCID http://orcid.org/0009-0001-5334-1891
Gary TincknellSchool of Science, University of Wollongong, Northfields Ave, North Wollongong, NSW, Australia.ORCID http://orcid.org/0000-0003-2611-0075
Simon A JoosseDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.ORCID http://orcid.org/0000-0002-4296-5615
Klaus PantelDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.ORCID http://orcid.org/0000-0001-5736-2772
Daniel BrungsSchool of Science, University of Wollongong, Northfields Ave, North Wollongong, NSW, Australia.ORCID http://orcid.org/0000-0002-8154-6966
Marie RansonSchool of Science, University of Wollongong, Northfields Ave, North Wollongong, NSW, Australia. mranson@uow.edu.au.ORCID http://orcid.org/0000-0002-5570-9645

Funding

Tour de Cure RSP-316-FY2023
6 · The paper itself

Abstract

Advanced oesophageal neuroendocrine carcinoma (ENEC) is a highly aggressive and rare malignancy with poor prognosis. Due to the rarity of this cancer there are currently no standardised treatment regimens for ENEC, and models to study this disease are difficult to obtain. To address this, we screened our established circulating tumour cell line from a patient with metastatic ENEC, termed UWG01CTC, using the LOPAC

Indexed as

Antineoplastic AgentsCarcinoma, NeuroendocrineEsophageal NeoplasmsOxidative StressApoptosisCell Line, TumorCell SurvivalHumansReactive Oxygen SpeciesAntineoplastic AgentsReactive Oxygen SpeciesAdaphostinCirculating tumour cellsCytotoxicityOesophageal neuroendocrine carcinomaReactive oxygen species

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.