ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Effect of membrane peeling on the ganglion cell inner-plexiform layer in glaucomatous eyes with idiopathic epiretinal membrane.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the impact of membrane peeling for idiopathic epiretinal membrane (iERM) on ganglion cell–inner plexiform layer (GCIPL) thickness in eyes with and without primary open-angle glaucoma (POAG).
methodsA total of 120 eyes (mean age 67.5 ± 10.0 years, female: 59%) were divided into four groups (n = 30 each): (1) POAG with iERM that underwent surgery, (2) non-glaucomatous with iERM that underwent surgery, (3) POAG without iERM, and (4) healthy control. Patients with iERM underwent pars-plana vitrectomy (PPV) with ERM and internal limiting membrane (ILM) peeling. GCIPL thickness within a 4 × 4.8 mm elliptical area was measured using Cirrus OCT (ZEISS, Dublin, CA) at baseline, 6 months, and 12 months postoperatively. Data collected included demographic and clinical parameters, best corrected visual acuity (BCVA), and intraocular pressure (IOP).
resultsA significant three-way interaction was observed between glaucoma, surgery, and time. POAG with iERM that underwent membrane peeling demonstrated greatest thinning, with mean change of − 9.40 μm at 6 months (95% CI: −15.07, − 3.73) and − 10.37 μm at 12 months (95% CI: −15.77, − 4.97), compared to all other groups (p < 0.001). BCVA significantly improved in non-glaucomatous eyes that underwent membrane peeling (p = 0.005), while remaining stable in the other groups. IOP remained stable across all time points.
conclusionsPPV with ILM and ERM peeling is associated with significant GCIPL thinning in glaucomatous eyes. These findings suggest a synergistic effect between glaucoma and surgical intervention, underscoring the need for caution when considering ILM peeling in glaucomatous patients.
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