ArticleOrganic letters2026
Synthesis of 5,5,6-Fused Tricyclic Lactones: Stereocontrol of Three Consecutive Stereocenters.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
We report a new, highly diastereoselective method for the synthesis of strained 5,5,6-fused tricyclic γ-lactones via a palladium-catalyzed tandem Heck/Suzuki cross-coupling reaction, followed by epoxidation and lactone-forming epoxide opening. Using this sequence, we prepared tricyclic γ-lactones with three consecutive stereocenters from simple, readily available starting materials, including one derived from enantiomerically pure biomass-based levoglucosenone. Our method provides a stereocontrolled approach to complex scaffolds of potential relevance in synthetic and medicinal chemistry.
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