Evidence map›Paper›PMID 41524521›Full record

ArticleJournal of bacteriology2026

YeiE regulates YeiH to implement sulfite stress resistance in

Trina L Westerman, Elly Scheuerell, Vivian H Nguyen, Kaiya Johnson, Michael McClelland, Johanna R Elfenbein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Trina L WestermanDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Elly ScheuerellDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vivian H NguyenDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kaiya JohnsonDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Michael McClellandDepartment of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California, USA.ORCID 0000-0003-1788-9347
Johanna R ElfenbeinDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4764-0713

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Mechanistic evaluation of resistance to sulfite toxicity in SalmonellaR21AI178071 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ELFENBEIN, JOHANNA REBECCA · 2023 to 2024
$442k
NCI NIH HHS P30 CA062203NIAID NIH HHS R21 AI178071NIGMS NIH HHS T32 GM140935NIH HHS R21AI178071
6 · The paper itself

Abstract

Sulfites are toxic, reactive sulfur species that are widespread in nature. Bacteria are exposed to sulfites during the metabolism of sulfur-containing amino acids, during respiration using sulfur-containing electron acceptors, in host environments, and as food preservatives. Despite the widespread distribution of sulfites, the mechanisms by which bacteria resist their toxic effects are poorly understood. Recent work showed that the LysR-type transcriptional regulator YeiE binds to sulfite to activate sulfite reduction gene expression. We show that YeiE is necessary for

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialSalmonella typhimuriumStress, PhysiologicalSulfitesTranscription FactorsAnimalsMiceBacterial ProteinsSulfitesTranscription FactorsSalmonella entericastress responsesulfitetranscriptional regulation

Identifiers

PMID41524521
PMCPMC12880088

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.