Evidence map›Paper›PMID 41524517›Full record

ArticleJournal of bacteriology2026

The staphylococcal type VII secretion system protein EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity.

Victoria Smith, Robeena Farzand, Giridhar Chandrasekharan, Kate E Watkins, Ramon Garcia Marset, Jeannifer Yap, Sebastien Perrier, Arnaud Kengmo Tchoupa, Meera Unnikrishnan

Abstract read
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victoria SmithDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Robeena FarzandDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.ORCID 0000-0001-7524-936X
Giridhar ChandrasekharanDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Kate E WatkinsDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Ramon Garcia MarsetDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Jeannifer YapDepartment of Chemistry, University of Warwick, Coventry, United Kingdom.
Sebastien PerrierDepartment of Chemistry and Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Arnaud Kengmo TchoupaDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.ORCID 0000-0003-0162-7051
Meera UnnikrishnanDivision of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom.ORCID 0000-0001-5417-9331

Funding

Biotechnology and Biological Sciences Research Council 2097375Medical Research Council MR/N010140/1, MR/X00161X/1
6 · The paper itself

Abstract

The human pathogen

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCell MembraneCell WallDaptomycinStaphylococcus aureusType VII Secretion SystemsAnimalsCalciumMembrane FluidityMiceMicrobial Sensitivity TestsStaphylococcal InfectionsAnti-Bacterial AgentsBacterial ProteinsCalciumDaptomycinType VII Secretion Systemsdaptomycinmembrane fluiditymembrane integritytype VII secretion system

Identifiers

PMID41524517
PMCPMC12918736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.