SynthesisPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2026
Perioperative Monitoring of Regional Oxygen Saturation in Congenital Heart Disease: Systematic Review of Literature up to 2023.
Synthesis in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Discrete cerebral oximetry measurements and the potential contribution of hemolysis to circulating neuron-specific enolase after pediatric cardiac surgery.Journal of intensive care · 2026Article
- Age-dependent cerebral oxygenation and brain injury in pediatric cardiac surgery: vulnerability of infants aged ≤6 months.Journal of intensive care · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePediatric patients with congenital heart disease (CHD) are at risk of non-cardiac complications that impact outcome. Early prognostication is necessary to tailor treatment and improve parent counseling. This systematic review assessed the prognostic value of perioperative near-infrared spectroscopy (NIRS) monitoring of regional oxygen saturation (rSO₂) with regard to brain injury, brain development, neurodevelopment, acute kidney injury (AKI), and necrotizing enterocolitis (NEC) in pediatric CHD patients. DATA SOURCES: PubMed and Embase databases. STUDY SELECTION: We searched for original research articles published up to 2023 describing children (younger than 18 yr) with CHD using perioperative rSO₂ monitoring, and reporting their association with at least one of the following outcomes: AKI, NEC, brain injury, brain development, or neurodevelopment. DATA EXTRACTION: Ten studies, including a total of 562 patients, were included for brain injury, 4 studies with 229 patients for brain development, 15 studies with 1024 patients for neurodevelopment, 15 studies with 1168 patients for AKI, and 3 studies including 250 patients for NEC. The majority of the studies had a moderate to high risk of bias as assessed by the Cochrane Quality in Prognosis Studies tool. High heterogeneity in study populations and NIRS measurements was found. DATA SYNTHESIS: Of the studies we identified, 5 of 10 in brain injury, 3 of 4 in brain development, 10 of 15 in neurodevelopment, 9 of 15 in AKI, and 1 of 3 in NEC reported associations with rSO₂. No meta-analysis could be performed due to heterogeneity.
conclusionsOur findings highlight the need to improve methodological quality and reduce intra- and interstudy heterogeneity. Several methodological recommendations to improve future research were formulated.
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