SynthesisJournal of global health2026
Invasive non-typhoidal Salmonella infections in China (1961-2024): a retrospective systematic analysis of multicentre case reports.
Synthesis in Journal of global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Wild birds as environmental reservoirs of antimicrobial-resistantFrontiers in microbiology · 2026Pooled it
- Salmonella species in foods of animal origin, their virulence potential and antibiotic susceptibility in India: implications for public health.Veterinary research communications · 2026Article
- Antibiotic Resistance Genes in Salmonella Isolates from Food Production Environments and Clinical Sources in the Middle East: A Systematic Review and Meta-Analysis Revealing the Limited Comparative Genomic Evidence.Life (Basel, Switzerland) · 2026Review
- Article
- One Health genomics reveals niche-specific lineage replacement inNational science review · 2026Article
- Distinct genomic trajectory among invasive Salmonella Typhimurium ST313 infections.Nature communications · 2026Article
- Persistence of non-typhoidalFrontiers in microbiology · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Salmonella can be classified as either typhoidal or non-typhoidal. The former primarily causes invasive infections, while the latter typically results in self-limiting diarrhoea. Infections caused by invasive non-typhoidal Salmonella (iNTS) are becoming an emerging global health burden, particularly in low- and middle-income regions. While they account for thousands of deaths each year, we still lack systematic analysis on their burden and epidemiology in Asia, particularly in China. Methods: We searched Web of Science, PubMed, China National Knowledge Infrastructure, Wanfang Data, Airiti Library, and the China Science and Technology Journal Database on 31 March 2024. The primary outcomes of interest included the spatiotemporal distribution of iNTS infection cases, patients' characteristics, and clinical outcomes. The secondary outcomes encompassed characterisation of isolates, medical histories, and medication usage. We used the Open Meta-Analyst software to estimate the case fatality rate. Results: We included 199 publications for analysis. Eastern regions of China were identified as hotspots for infection, males and children were especially susceptible populations, while trauma and metabolic diseases emerged as major risk factors associated with infection. Typhimurium, Choleraesuis, and Enteritidis were the top three serovars responsible for infections, with the bloodstream being the most frequent site of invasion. The overall case-fatality rate of iNTS in China was 8.6% (95% confidence interval = 6.8-10.4). Conclusions: In exploring the epidemiological trends of iNTS infections in China, we observed significant risk associations with both patient characteristics and pathogen-specific determinants. There is an urgent need to establish enhanced surveillance systems and implement geographically tailored interventions+, particularly in economically underdeveloped regions. Registration: PROSPERO (CRD42024569499).
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