ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
A Self-Organized Liquid Reaction Container for Cellular Memory.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A kinetic proofreading argument to understand the role of H3K9 trimethylation in phase-separated chromatin states.Biophysical journal · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Epigenetic inheritance during cell division is essential for preserving cell identity by stabilizing the overall chromatin organization. Heterochromatin, the condensed and transcriptionally silent fraction of chromatin, is marked by specific epigenetic modifications that are diluted during each cell division. Here, we build a physical model, based on the formation of a biomolecular condensate, a liquid 'droplet', that promotes the restoration of epigenetic marks associated with heterochromatin. Heterochromatin facilitates the droplet formation via polymer-assisted condensation (PAC). The resulting condensate serves as a reaction chamber to reconstruct the lost epigenetic marks. We incorporate the enzymatic reactions into a particle-based simulation and monitor the progress of the heterochromatic epigenetic markers through an in silico analogue of the cell cycle. We demonstrate that the proposed mechanism is robust and stabilizes the heterochromatin domains over many cell generations. This mechanism and variations thereof might be at work for other epigenetic marks as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.