Evidence map›Paper›PMID 41524130›Full record

Observational studyClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Infections After Kidney Transplantation From Donors With HIV to Recipients With HIV.

Elizabeth C Arant, Thibaut Davy-Mendez, Tao Liang, Moreno Rodrigues, Cynthia L Gay, Meenakshi M Rana, Rachel Friedman-Moraco, Alexander Gilbert, Peter Stock, Sapna A Mehta and 30 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02602262 (Observational Study of HIV+ Deceased Donor Solid Organ Transplant for HIV+ Recipients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02602262 completednot on this map

Observational Study of HIV+ Deceased Donor Solid Organ Transplant for HIV+ Recipients

TypeobservationalSponsorJohns Hopkins UniversityRan2015 to 2023Enrolled105ConditionsHIV InfectionArmsHIV-infected deceased donor organ
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

40 authors.

Elizabeth C ArantDepartment of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-4378-279X
Thibaut Davy-MendezDepartment of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-8505-9268
Tao LiangDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6355-5546
Moreno RodriguesDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cynthia L GayDepartment of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3620-3059
Meenakshi M RanaDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Rachel Friedman-MoracoDepartment of Medicine, Emory University, Atlanta, Georgia, USA.
Alexander GilbertDepartment of Medicine, Georgetown University, Washington District of Columbia, USA.ORCID 0000-0001-5069-1880
Peter StockDepartment of Surgery, University of California, San Francisco, San Francisco, California, USA.
Sapna A MehtaDepartment of Medicine, NYU Langone Transplant Institute, New York, New York, USA.ORCID 0000-0002-5588-905X
Shikha MehtaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Valentina StosorDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-0388-5460
Marcus R PereiraDepartment of Medicine, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-9214-9122
Michele I MorrisDepartment of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.ORCID 0000-0002-4479-8726
Jonathan HandDepartment of Medicine, Ochsner Health, New Orleans, Louisiana, USA.ORCID 0000-0002-5752-9576
Saima AslamDepartment of Medicine, University of California, San Diego, La Jolla, California, USA.
Maricar MalinisDepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-5720-9994
Ghady HaidarDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Catherine B SmallDepartment of Medicine, Weill Cornell Medicine, New York, New York, USA.
Carlos A Q SantosDepartment of Medicine, Rush University Medical Center, Chicago, Illinois, USA.ORCID 0000-0002-6224-0371
Joanna SchaenmanDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
John W BaddleyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-9111-625X
David WojciechowskiDepartment of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-9170-9338
Emily A BlumbergDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5193-6170
Karthik RangannaDepartment of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Oluwafisayo AdebiyiDepartment of Medicine, Indiana University Health, Indianapolis, Indiana, USA.
Nahel EliasDepartment of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-6466-7347
Jose A Castillo-LugoDepartment of Medicine, Methodist Health System Clinical Research Institute, Dallas, Texas, USA.
Emmanouil GiorgakisDepartment of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-5019-5497
Senu ApewokinDepartment of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Megan MorsheimerNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-8237-3094
Christian van DeldenTransplant Infectious Diseases Unit, Service of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland.
Oriol ManuelDepartment of Medicine, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0001-7607-0943
Nicolas J MuellerDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-1059-3191
Dionysios NeofyotosTransplant Infectious Diseases Unit, Service of Infectious Diseases, University Hospital Geneva, Geneva, Switzerland.ORCID 0000-0001-6970-2869
Aaron A R TobianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Allan MassieDepartment of Surgery, NYU Langone Transplant Institute, New York, New York, USA.ORCID 0000-0002-5288-5125
Dorry L SegevDepartment of Surgery, NYU Langone Transplant Institute, New York, New York, USA.ORCID 0000-0002-1924-4801
William WerbelDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christine M DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2605-9257

Funding

HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term OutcomesU01AI177211 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2023 to 2026
$6.9M
Unlocking the Potential of HIV-Infected Deceased Donors for Organ TransplantationR01AI120938 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2016 to 2021
$4.3M
T-cell depletion and maintenance of the HIV-1 latent reservoir in distinct tissue compartmentsR01DK131926 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Melissa Laird Smith, AARON A TOBIAN · 2022 to 2026
$3.6M
The Landscape of Serious Infections following Kidney Transplantation in People Living with HIVK23AI157893 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WERBEL, WILLIAM · 2021 to 2025
$847k
Addressing Barriers to the Comprehensive Use of Statins in HIV: The ABACUS-HIV StudyK01HL169020 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thibaut Davy-Mendez · 2023 to 2026
$600k
NHLBI NIH HHS K01 HL169020NIH HHS K23AI157893NIH HHS R01AI120938NIH HHS R01DK131926NIH HHS U01AI134591NIH HHS U01AI138897NIH HHS U01AI177211
6 · The paper itself

Abstract

backgroundKidney transplantation (KT) from donors with human immunodeficiency virus (HIV-1) to recipients with HIV (HIV D+/R+) is noninferior to KT from donors without HIV (HIV D-/R+) with regard to safety. However, there may be differences in posttransplant infections.

methodsWe performed a secondary analysis of the HOPE in Action KT Study (NCT02602262) comparing the time to first clinically relevant infection within 24 months posttransplantation in 99 HIV D+/R+ versus 99 HIV D-/R+. Secondary outcomes included incidence rates, infection-related death, and timing of clinically relevant infection, each stratified by donor HIV status.

resultsThe cumulative incidence of a clinically relevant infection at 24 months posttransplantation was 73.8% (95% confidence interval [CI]: 63.1%-81.2%) for HIV D+/R+ versus 64.7% (95% CI: 53.0%-73.4%) for HIV D-/R+. Comparing time to first clinically relevant infection in HIV D+/R+ versus HIV D-/R+, the adjusted hazard ratio (aHR) was 1.44 (95% CI: 1.01-2.04) at 24 months posttransplantation; for infections associated with hospitalization, the aHR was not significantly higher (1.21 [95% CI: .78-1.86). There were no significant differences in the number of infections, death from infection, duration, or site of infection between HIV D+/R+ versus HIV D-/R+, though viral infections were numerically more common in HIV D+/R+ (40% vs 35%).

conclusionsAlthough there was a statistically significant association between receipt of a kidney from a donor with HIV and time to first clinically relevant infection in the 24 months posttransplantation, there were no differences in infections associated with hospitalization. These data are overall reassuring as this emerging practice expands into clinical care. Clinical Trials Registration. NCT02602262.

Indexed as

HIV InfectionsKidney TransplantationTissue DonorsTransplant RecipientsAdultFemaleHumansIncidenceMaleMiddle AgedHIVHOPE Actinfectionkidney transplantkidney transplantation

Identifiers

PMID41524130
PMCPMC13016985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.