Evidence map›Paper›PMID 41524089›Full record

Trial reportMovement disorders clinical practice2026

Convergence Deficits in Myoclonus-Dystonia Point to Cerebellar Impairment.

Skadi Gerkensmeier, Christina Bolte, Jan-Ole Radecke, Feline Hamami, Andreas Sprenger, Christoph Helmchen, Robert Chen, Marcus Callister, Talyta Cortez Grippe, Christine Klein and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Skadi GerkensmeierDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.ORCID https://orcid.org/0009-0002-4844-4375
Christina BolteInstitute of Systems Motor Science, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0009-0006-2229-104X
Jan-Ole RadeckeDepartment of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-2115-9603
Feline HamamiInstitute of Systems Motor Science, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-1324-2776
Andreas SprengerDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.ORCID https://orcid.org/0000-0001-9255-7911
Christoph HelmchenDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.ORCID https://orcid.org/0000-0003-2493-2294
Robert ChenKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-8371-8629
Marcus CallisterKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-9871-038X
Talyta Cortez GrippeKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-3126-8002
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-2102-3431
Norbert BrüggemannDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.ORCID https://orcid.org/0000-0001-5969-6899
Tobias BäumerDepartment of Neurology, University Hospital Schleswig-Holstein, Lübeck, Germany.ORCID https://orcid.org/0000-0003-1014-1782
Alexander MünchauInstitute of Systems Motor Science, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-3219-2284
Anne WeissbachInstitute of Systems Motor Science, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-3569-6242

Funding

Deutsche Forschungsgemeinschaft LE 1122/7-1Deutsche Forschungsgemeinschaft WE5919/2-Dystonia Medical Research Foundation
6 · The paper itself

Abstract

backgroundMyoclonus-dystonia (M-D) is a monogenic movement disorder, with proposed cerebellar dysfunction. Vergence eye movement deficits, characteristics of degenerative cerebellar disease, have not been studied in M-D. Cerebellar transcranial alternating current stimulation (tACS) is considered a potential therapeutic approach.

objectivesTo assess vergence and prosaccade performance as markers of cerebellar dysfunction in M-D and to evaluate the effects of cerebellar 50 Hz tACS on these eye movements.

methodsVergence and prosaccade performance were examined in 14 M-D patients carrying pathogenic SGCE variants and 14 healthy controls. A subgroup (n = 7) received real and sham 50 Hz cerebellar tACS in a randomized, double-blind design.

resultsM-D patients showed prolonged latency and reduced gain of convergence compared to controls. Divergence did not differ between groups. Prosaccade peak velocity was reduced in M-D patients. 50 Hz cerebellar tACS showed no effect on eye movements.

conclusionImpaired convergence supports cerebellar involvement in M-D. Further studies should identify affected pathways.

Indexed as

Cerebellar DiseasesConvergence, OcularDystonic DisordersOcular Motility DisordersAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedSarcoglycansTranscranial Direct Current StimulationYoung AdultSarcoglycansSGCE protein, humancerebellumepsilon‐sarcoglycanmyoclonus‐dystoniatACSVergence eye movements

Identifiers

PMID41524089
PMCPMC13306908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.