ArticleNAR genomics and bioinformatics2026
Structural analysis of uridine modifications in solved RNA structures.
Article in NAR genomics and bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Naturally occurring uridine modifications in RNA play critical roles in modulating RNA stability, translation, and immune responses. While detection methods have advanced, a comprehensive structural analysis across experimentally determined RNA 3D structures remains limited. In this study, we systematically examined six uridine modifications-pseudouridine (PSU), 5-methyluridine (5MU), 3-methyluridine (UR3), O2'-methyluridine (OMU), 4-thiouridine (4SU), and 5,6-dihydrouridine (H2U)-using data from the Research Collaboratory for Structural Bioinformatics Protein Data Bank. After curation, we identified 2982 PSU, 736 5MU, 232 UR3, 429 OMU, 314 4SU, and 171 H2U residues across RNA-containing structures. These modifications were primarily found in ribosomal and transfer RNAs, often localized within hairpin secondary structures. Sugar pucker analysis revealed modification-specific preferences for C3'-
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