Evidence map›Paper›PMID 41523973›Full record

ArticleAlpha psychiatry2025

Altered Low-beta Characteristics in Individuals With Alcohol Use Disorder: A Pilot Resting Electroencephalography Study.

Bing Li, Jie Wang, Shuaiyu Long, Jinyun Hu, Lili Zhang, Wei Cui, Yunshu Zhang, Chaomeng Liu

Abstract read
In one paragraph

Article in Alpha psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bing LiHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0000-0002-6491-3330
Jie WangHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0009-0002-7876-218X
Shuaiyu LongHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0009-0001-2859-1522
Jinyun HuHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0009-0005-7822-5933
Lili ZhangHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0000-0002-2334-6755
Wei CuiHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0009-0004-0102-8264
Yunshu ZhangHebei Provincial Mental Health Center, 071000 Baoding, Hebei, China.ORCID https://orcid.org/0009-0009-9307-4335
Chaomeng LiuThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, 100088 Beijing, China.ORCID https://orcid.org/0000-0002-2461-4723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The pathophysiological mechanisms underlying alcohol use disorder (AUD) remain unclear, and its clinical evaluation largely depends on subjective assessments lacking objective biomarkers. This study employed a case-control design incorporating resting-state electroencephalography (EEG) with power spectral analysis (PSA) and dynamic functional connectivity (dFC) to explore potential biomarkers for AUD. Methods: Resting-state EEG data were collected from individuals diagnosed with AUD and demographically matched healthy controls (HCs), alongside comprehensive neuropsychological and behavioral evaluations. PSA quantified energy distribution across specific frequency bands, with receiver operating characteristic analysis determining its discriminatory capacity. dFC was examined using a sliding window approach and the weighted phase-lag index, followed by K-means clustering to extract dominant connectivity states across frequency bands. Results: After excluding cases with suboptimal EEG data, the final analytic sample comprised 25 individuals with AUD and 26 HCs. Compared to HCs, the AUD group exhibited elevated low-beta power at F1, FCz, FC1, and C3 electrode sites (10-20 EEG system), with respective area under the curve values of 0.795, 0.794, 0.806, and 0.769, indicating reliable group differentiation. Temporal profiling of functional connectivity revealed three distinct brain states: S1 (60.81%), S2 (21.05%), and S3 (18.15%). Correlations between these connectivity patterns and clinical indices were observed in the AUD cohort. Conclusion: Individuals with AUD showed increased brain activity in the medial frontal gyrus and left central gyrus at rest, as well as significant low-beta frequency changes in dFC analysis. Resting EEG scans with PSA and dFC analysis could serve as potential biomarkers for detecting AUD.

Indexed as

alcohol use disorderdynamic functional connectivityelectroencephalographyk-means clustering

Identifiers

PMID41523973
PMCPMC12781204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.