ArticleAlpha psychiatry2025
The Effect of Comorbid Major Depressive Disorder on Working Memory in Young Adults With ADHD and the Mediating Role of the DLPFC.
Article in Alpha psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Attention-Deficit/Hyperactivity Disorder (ADHD) and Major Depressive Disorder (MDD) both exhibit working memory (WM) impairments and frequently co-occur. However, the impact of comorbid MDD on WM in ADHD patients and the underlying mechanisms remain unclear. Methods: The study included 409 adults, comprising 125 ADHD patients comorbid with MDD (ADHD+MDD), 145 ADHD patients without MDD (ADHD-MDD), and 139 healthy controls. In addition, functional connectivities (FCs) with the region of interest-the dorsolateral prefrontal cortex (DLPFC)-were analyzed in a subsample to explore the potential underlying neural mechanism. Results: The WM scores of the ADHD+MDD group were higher than those of the ADHD-MDD group. In all ADHD patients, depression scores were positively correlated with the WM impairment scores and explained 3.6% of the variance in WM impairment. Mediation analysis detected a potential effect of ADHD diagnosis on WM impairment via depressive symptoms. WM-related FC was identified between the left DLPFC and the right supramarginal gyrus (FC Conclusions: MDD in adults with ADHD exacerbated WM impairment, which may be related to the FC alteration between the left DLPFC and the right supramarginal gyrus (SMG). This finding provides a scientific basis for a deeper understanding of the pathogenesis and brain biomarkers of ADHD+MDD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.