Evidence map›Paper›PMID 41523881›Full record

ArticleInternational journal of pediatrics2026

Pulmonary Peak Flow Assessment: An Easy Tool for Cardiac Output Estimation in Hemodynamically Stable Neonates.

Angela Alfarano, Roberto Marzollo, Serena Amighetti, Cesare Tomasi, Maria Ilaria Bosio, Salvatore Aversa, Elena Borelli, Mario Motta, Francesco Maria Risso

Abstract read
In one paragraph

Article in International journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Angela AlfaranoDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-0257-0387
Roberto MarzolloDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0001-8468-5999
Serena AmighettiDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0009-0007-9305-5893
Cesare TomasiDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-3699-8744
Maria Ilaria BosioDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-3157-036X
Salvatore AversaDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0003-2634-1498
Elena BorelliDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0003-2965-6428
Mario MottaDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-9579-2455
Francesco Maria RissoDepartment of Neonatology and Neonatal Intensive Care, Children's Hospital, ASST Spedali Civili of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-5799-0522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Right ventricular output (RVO) assessment can estimate systemic blood flow (SBF) in neonates but requires advanced echocardiography expertise. Pulmonary peak flow (PPF) could be an easier surrogate for RVO. This study is aimed at evaluating the correlation between RVO and PPF in neonates and assessing their intraobserver variability. Methods: In this single-center, longitudinal, observational study, we included term and preterm neonates admitted to our Neonatal Intensive Care Unit between February and July 2022. A neonatologist with experience in functional echocardiography recorded targeted neonatal scans. Recordings were analyzed off-line for echocardiographic measurements. After 12 months, a second analysis of the recordings was performed by the same examiner to avoid recall bias. We compared the two analyses for intraobserver variability assessment. Results: We analyzed a cohort of 33 term and preterm infants. We found a strong positive correlation between RVO and PPF ( Conclusions: Our findings support the use of PPF as a surrogate for RVO for cardiac output estimation in term and preterm neonates. Because of its simplicity, rapidity, and low intraobserver variability, PPF could be a useful tool for SBF assessment. Future studies should be performed to evaluate the correlation between PPF and other echocardiographic markers of low SBF.

Indexed as

echocardiographyneonatal intensive care unitpreterm infantsright ventricular outputsystemic blood flow

Identifiers

PMID41523881
PMCPMC12781998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.