ArticleThe Pan African medical journal2025
Investigation of the relationship between uterine artery Doppler diastolic notching and serum apelin-13 and apelin-36 concentrations between the 11
Article in The Pan African medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: the apelin family plays a role in the proliferation and migration of trophoblasts. Based on this, we aimed to investigate the relationship between diastolic notching in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations between 11 and 14 weeks of gestation. Methods: forty-four (44) pregnant women with diastolic notching in uterine artery Doppler and 44 without diastolic notching were compared in terms of serum apelin-13 and apelin-36 concentrations. Results: the two groups were similar in terms of demographic characteristics (p > 0.05). The median apelin-13 concentration was found to be 45.4 pg/mL in the uterine artery notch-positive group, while it was 41.02 pg/mL in the uterine artery notch-negative group (p = 0.770). The median apelin-36 concentration was 546.06 pg/mL in the uterine artery notch-positive group, while it was 536.6 pg/mL in the uterine artery notch-negative group (p = 0.570). Participants were regrouped as high or normal pulsatility index (PI) according to uterine artery PI, and both groups were compared in terms of apelin-13 and apelin-36 concentrations. Median serum apelin-13 and apelin-36 concentrations were also similar in the high and normal uterine artery PI groups (p = 0.445, p = 0.402, respectively). Conclusion: although the number of participants was too small to draw a definitive conclusion, no significant relationship between diastolic notching or increased resistance in the uterine artery and serum apelin-13 and apelin-36 concentrations could be detected.
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