ArticleWorld journal of experimental medicine2025
Concordance of programmed death-ligand 1 expression assessments determined
Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer.World journal of experimental medicine · 2026Article
- Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant.World journal of experimental medicine · 2025Article
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5 authors.
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Abstract
backgroundWe previously demonstrated that the antibody against programmed cell death protein 1 ligand 1 (PDCD1 LG1) is a promising new marker of programmed death-ligand 1 (PD-L1) expression that correlates with both breast cancer (BC) clinicopathological characteristics and tumor sensitivity to chemotherapy. However, the concordance of PDCD1 LG1 expression scoring with immunohistochemical (IHC) tests approved for clinical use and with the polymerase chain reaction (PCR) method has not been previously studied.
aimTo evaluate the concordance of methods for assessing PD-L1 expression, IHC tests with anti-PD-L1 (PDCD1 LG1) and anti-PD-L1 (SP142) antibodies and PCR.
methodsThis prospective single-center observational cohort study included 148 patients with BC. PD-L1 expression in immune cells was assessed by the IHC method with anti-PD-L1 (PDCD1 LG1) and anti-PD-L1 (SP142) antibodies and by PCR. The concordance of PD-L1 scores between tests was assessed with positive percentage agreement (PPA) and negative percentage agreement (NPA). The strength of the agreement between the methods was calculated
resultsRegardless of the method used to assess marker expression, PD-L1 expression was significantly more often detected in patients with negative estrogen receptor status, human epidermal growth factor receptor-2-positive (HER2+) status, luminal B HER+ BC, nonluminal HER+ BC and triple-negative BC. PPA and NPA were 38.3% and 70.4%, respectively, for PD-L1 (PDCD1 LG1) and PD-L1 (SP142); 26.3% and 63.3%, respectively, for PD-L1 (PDCD1 LG1) and PD-L1 (PCR); and 36.5% and 74.4%, respectively, for PD-L1 (SP142) and PD-L1 (PCR). Cohen's kappa index for PD-L1 (PDCD1 LG1) and PD-L1 (SP142) was 0.385 (95%CI: 0.304-0.466), that for PD-L1 (PDCD1 LG1) and PD-L1 (PCR) was 0.207 (95%CI: 0.127-0.287), and that for PD-L1 (SP142) and PD-L1 (PCR) was 0.389 (95%CI: 0.309-0.469).
conclusionThus, all three markers of PD-L1 expression are associated with the characteristics of aggressive BC, demonstrating moderate concordance between the tests.
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