ArticleWorld journal of experimental medicine2025
Genotoxic damage assessment using the micronucleus assay in buccal mucosa of different types of smokers: A cross-sectional study.
Article in World journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSmoking is a leading cause of carcinogenesis in the head and neck region, representing a critical public health issue. Identifying genotoxic damage in smokers can provide valuable insights for developing preventive interventions.
aimTo assess genotoxic damage through the micronucleus assay in exfoliated buccal mucosa cells from users of conventional tobacco, reverse smoking, cannabis, electronic cigarettes, and non-smokers.
methodsA cross-sectional study was conducted with 100 participants divided into five groups: 20 conventional tobacco smokers, 20 reverse smokers, 20 electronic cigarette users, 20 cannabis users, and 20 non-smokers. Exfoliated buccal mucosa cells were analyzed using Giemsa and Papanicolaou staining to identify micronuclei (MN) as markers of genotoxic damage.
resultsMN were present in 86% of the samples. Statistically significant differences were observed in the median micronucleus count between conventional, reverse, and electronic cigarette smokers compared to non-smokers (
conclusionThis study identified genotoxic damage associated with various smoking habits, except for cannabis use, highlighting the need for public health interventions to reduce smoking and mitigate its genotoxic effects. These findings provide a foundation for future research and the implementation of preventive policies.
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