ArticleFood science and biotechnology2026
Lariciresinol and secoisolariciresinol enhance myogenic differentiation and mitochondrial biogenesis in C2C12 myotubes.
Article in Food science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploring the Health Effects of Phytoestrogens.Metabolites · 2026Review
- Phytochemical-Based Therapeutic Strategies for Sarcopenia: From Molecular Mechanisms to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lariciresinol (LR) and secoisolariciresinol (SLR), phytochemicals found in pine bark and flaxseed, are known for their anticancer effects, risk reduction of cardiovascular disease, hormone regulation, and antioxidant activities. However, researches on their effects on skeletal muscle function are scarce. Therefore, this study aimed to investigate the efficacy of LR and SLR in promoting muscle hypertrophy and mitochondrial function in C2C12 mouse-derived myoblasts. LR and SLR were found to enhance myogenic differentiation as indicated by increased fusion index via myotube immunostaining and upregulation of MHC-Myogenin expression. These effects are caused by upregulated Akt phosphorylation, which is associated with protein synthesis pathways. In addition, LR and SLR supplementation led to increased mitochondrial biogenesis and enhanced mitochondrial function through upregulation of PGC-1α/SIRT1. These findings indicate that LR and SLR supplementation promotes muscle development and suggests potential for the prevention and treatment of sarcopenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.