Evidence map›Paper›PMID 41523629›Full record

ArticleJournal of clinical and translational science2025

"Deserved Trust": Perspectives in trust and trustworthiness by biomedical researchers in clinical and translational sciences.

Sylk Sotto-Santiago, Melissa Pangelinan, Zoe Orrel, Ian Jones, Dustin O Lynch, Brenda Hudson, Sarah E Wiehe

Abstract read
In one paragraph

Article in Journal of clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sylk Sotto-SantiagoDepartment of Medicine, Associate Vice Chancellor for Faculty Development and Inclusive Excellence, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-3810-1205
Melissa PangelinanIndiana Clinical and Translational Sciences Institute, Indianapolis, IN, USA.
Zoe OrrelIndiana University School of Medicine, Indianapolis, IN, USA.
Ian JonesIndiana University School of Medicine, Indianapolis, IN, USA.
Dustin O LynchIndiana Clinical and Translational Sciences Institute, Indianapolis, IN, USA.
Brenda HudsonIndiana Clinical and Translational Sciences Institute, Indianapolis, IN, USA.
Sarah E WieheIndiana Clinical and Translational Sciences Institute, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0002-8148-0848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Trust in biomedical research is essential, multidimensional, and shaped by individual experiences, culture, and communication. Participants' trust relies on researchers' commitment to ethical practices. As public trust in science declines due to misinformation and disinformation campaigns, biomedical researchers (BmRs) must ensure trust and cultivate trustworthiness. This study explores BmR's perspectives on trust and trustworthiness. Methods: We employed a qualitative, phenomenological approach to explore the experiences of BmRs. Through purposive sampling via the Indiana Clinical and Translational Sciences Institute, we invited BmRs to participate in semi-structured interviews. We employed rapid qualitative analysis (RQA) to identify key themes from interviews with BmRs. This action-oriented approach enables a research team to efficiently summarize experiences and perspectives, using structured templates and matrixes for systematic analysis and interpretation. Results: Fourteen BmRs were interviewed. Volunteer demographics were collected for race/ethnicity, gender, faculty rank, and investigator experience level. The following domains were identified: individual trust and trustworthiness, institutional trustworthiness, and trust and equity as a crucial part of structural and social drivers of health. Conclusion: We recognize that BmRs are dedicated to health equity and addressing disparities. However, in addition to committing to "best practices," BmRs should prioritize actions that foster genuine trust from the communities they serve. More development opportunities are needed for reflection of what it means to be trusted by research volunteers and communities. Furthermore, intentions alone aren't sufficient; earned trust and trustworthiness are vital.

Indexed as

clinical trialscommunity engagementdiversityhealth equityrecruitmentTrusttrustworthiness

Identifiers

PMID41523629
PMCPMC12780794

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.