Evidence map›Paper›PMID 41523580›Full record

ArticleInternational journal of genomics2026

Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer.

Chunbiao Wu, Hao Jiang, Wei Xu, Bo Li, Hao Zhang, Long Zhang, Zhenxi Li, Jianru Xiao, Pengpeng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunbiao WuInstitute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China, usst.edu.cn.ORCID https://orcid.org/0009-0003-5456-9681
Hao JiangDepartment of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China, smmu.edu.cn.ORCID https://orcid.org/0000-0002-6423-7643
Wei XuDepartment of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China, smmu.edu.cn.ORCID https://orcid.org/0000-0001-9465-1880
Bo LiDepartment of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China, smmu.edu.cn.ORCID https://orcid.org/0009-0005-3775-8637
Hao ZhangDepartment of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China, smmu.edu.cn.ORCID https://orcid.org/0009-0001-4466-8796
Long ZhangInstitute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China, usst.edu.cn.ORCID https://orcid.org/0009-0009-1139-6737
Zhenxi LiInstitute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China, usst.edu.cn.ORCID https://orcid.org/0000-0002-7220-6177
Jianru XiaoInstitute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China, usst.edu.cn.ORCID https://orcid.org/0009-0003-1763-7681
Pengpeng ZhangInstitute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China, usst.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence highlights the pivotal role of KISS1 in cancer metastasis; however, there remains a dearth of pancancer analyses, particularly concerning immunotherapy. Here, we conducted a comprehensive investigation of KISS1 across various cancers, with a specific focus on breast cancer, using TCGA and GTEx datasets. We observed a tissue context-dependent role function of KISS1 in tumor metastasis, which exhibited suppressive effects in various tumors but promoted the metastatic phenotype in breast cancer. Our study revealed a noteworthy disparity between KISS1 expression at the mRNA and protein levels, indicating potential posttranslational modifications within cancer cells. Moreover, KISS1 is significantly associated with immune cell infiltration and immunosuppressive cells, suggesting its crucial role in modulating tumor immunotherapy. Intriguingly, our investigation also elucidated KISS1's involvement in promoting breast cancer metastasis, thereby providing valuable insights into the molecular underpinnings of this process. Furthermore, we validated the presence of posttranslational modifications of KISS1 in breast cancer, adding to our understanding of its role in tumorigenesis. By shedding light on the tissue context-dependent function of KISS1 and its implications for immunotherapy, our pancancer study offers novel perspectives on the oncogenic roles of KISS1 and provides potential avenues for the development of targeted therapies and diagnostic biomarkers.

Indexed as

biomarkerbreast cancerimmune infiltrationKISS1posttranslational modificationtumor metastasis

Identifiers

PMID41523580
PMCPMC12780545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.