ReviewCureus2025
Thyrotoxic Periodic Paralysis (TPP): A Comprehensive Review with Regional Insights from the Middle East.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Lifestyle and dietary measures in Periodic Paralyses.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2026Review
- Thyrotoxic Periodic Paralysis Following a 75-g Oral Glucose Load Revealing Previously Undiagnosed Graves' Disease: A Case Report.Clinical medicine insights. Case reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyrotoxic periodic paralysis (TPP) is a rare but potentially life-threatening cause of acute flaccid paralysis, characterized by hypokalemia in the setting of thyrotoxicosis and often misdiagnosed in emergency departments.
methodsWe conducted a narrative literature review of TPP in adults using major databases up to 31 October 2025, with a focus on clinical presentation, precipitants, diagnostic pitfalls, and management, and we synthesized Middle Eastern case data alongside global experience.
resultsTPP typically affects younger males and may be the first manifestation of hyperthyroidism. High-carbohydrate meals, strenuous exercise, and β-agonists are common triggers. Misdiagnosis as Guillain-Barré syndrome or other neuromuscular conditions is frequent, particularly when thyrotoxicosis is subtle. Middle Eastern reports suggest similar clinical patterns but highlight delayed recognition and variable access to thyroid testing. Early correction of hypokalemia, non-selective beta (β)-blockade, and definitive control of thyrotoxicosis are essential to prevent recurrences.
conclusionsAn emergency department (ED)-focused approach that routinely considers TPP in acute flaccid paralysis, integrates rapid thyroid function testing, and follows structured potassium replacement and β-blocker protocols can reduce diagnostic delay and improve outcomes. Incorporating regional data may help tailor awareness campaigns and management pathways in Middle Eastern and other underrepresented settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.