ArticleCureus2025
A Retrospective Study on the Use of C-reactive Protein and Neutrophil-Lymphocyte Ratio as Predictive Markers to Prevent Unnecessary Appendicectomy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSymptomatology of acute appendicitis is a common presentation in children and biochemical markers are often utilised to differentiate acute appendicitis from other pathologies. The aim of this study is to assess the utility of C-reactive protein (CRP) and neutrophil-lymphocyte ratio compared to standard biochemical markers in predicting acute appendicitis and preventing unnecessary appendicectomy.
methodsThis is a single-centre retrospective cohort study of paediatric patients <16 years who presented to Ipswich Hospital with symptomatology of acute appendicitis between January 2019 to January 2024. Five hundred ninety-three patients were screened against inclusion/exclusion criteria and 582 patients were available for analysis.
resultsThe study identified CRP (OR 1.009), neutrophil-lymphocyte ratio (NLR) (OR 0.909), neutrophil count (OR 1.222), and lymphocyte count (OR 0.708) to be significant coefficients in predicting acute appendicitis following logistic regression analysis. CRP was found to be a superior predictor of acute appendicitis following receiver operating characteristic (ROC) analysis (area under the curve (AUC) 0.712, sensitivity 75.60%, specificity 61.48%, p<0.001) compared to NLR, neutrophil and lymphocyte count.
conclusionIn this large study, we have validated the effectiveness of certain biomarkers as predictive markers for acute appendicitis in children, potentially reducing the risk of unnecessary appendicectomy. CRP is superior to NLR, neutrophil and lymphocyte count in predicting acute appendicitis. The use of CRP, in addition to other markers such as NLR, is valuable in preventing unnecessary appendicectomy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.