ArticleCureus2025
D-Dimer: An Early Marker of Disseminated Intravascular Coagulation in Preeclampsia and Eclampsia.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Introduction Preeclampsia, a disease of unknown etiology, affects multiple organ systems and carries a grave prognosis for both the mother and fetus. Any hypertension and proteinuria developing after 20 weeks of gestation in a previously normal patient warrants investigation for this disease. Coagulation studies may be deranged in preeclampsia and eclampsia due to their association with disseminated intravascular coagulation (DIC). In DIC, the underlying basic pathology is endothelial dysfunction and intense vasospasm; it can affect any organ but most commonly affects the brain, kidneys, uterus, and placenta. Materials and method This retrospective cross‑sectional study was conducted on a sample size of 432 subjects over a two-year period in a tertiary referral center. Two categories of patients were identified and selected: preeclampsia patients and the control group, which comprised other admitted pregnant patients age-matched with the study group. Patient data were entered into Excel and analyzed using SPSS Statistics Version 24. Continuous variables were represented as mean and standard deviation (SD), while categorical variables were represented as frequency and percentage. Statistical analysis was performed using a parametric test of ANOVA. Significance level (p-value) was 0.05. Results Among the patients, 180 (41.7%) patients were nullipara, while 252 (58.3%) were multipara. All patients showed hypertension, with 382 (88.4%) patients having blood pressure values between 140/90 and 160/110 mmHg and 50 (11.2%) having values above 160/110 mmHg. Among the patients, 191 (44.2%) had grade 2 proteinuria, 79 (18.2%) had grade 3 proteinuria, and 18 (4.2%) had grade 4 proteinuria, as determined by the dipstick method. Additionally, 148 (34%) subjects had platelet count < 150,000/mm
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