Ulcerative Necrobiosis Lipoidica in the Setting of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma and Glucose-6-Phosphate Dehydrogenase Deficiency.

Mary J Casey, Francesca L Veon, Anisha Bhanot, Brad Gehrs, Jeffrey D McBride

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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mary J CaseyCollege of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Francesca L VeonMark Allen Everett Department of Dermatology, University of Oklahoma Health Campus, Oklahoma City, USA.

Anisha BhanotMark Allen Everett Department of Dermatology, University of Oklahoma Health Campus, Oklahoma City, USA.

Brad GehrsDepartment of Pathology, University of Oklahoma Health Campus, Oklahoma City, USA.

Jeffrey D McBrideMark Allen Everett Department of Dermatology, University of Oklahoma Health Campus, Oklahoma City, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrobiosis lipoidica (NL) is a chronic granulomatous disease most commonly manifesting as yellow, atrophic plaques and ulcerations on the lower extremities. We present an exacerbation of NL in a patient with a known history of glucose-6-phosphate dehydrogenase deficiency, who, following a clinical and histopathologic diagnosis of NL, was found to have oropharyngeal Epstein-Barr virus-positive diffuse large B-cell lymphoma. After implementation of therapies for lymphoma, chemotherapeutic complications, and NL, the patient reported improvement in both pain and ulcerations. Though noninfectious granulomatous reactions are common in lymphoproliferative disorders, the skin is rarely involved. This case presentation provides evidence for an association between NL and underlying lymphoma development and encourages clinicians to rule out lymphomatous processes in the setting of reoccurring or recalcitrant noninfectious cutaneous granulomas.

Indexed as

diffuse large b-cell lymphomaepstein barr virus positiveglucose-6-phosphate dehydrogenase deficiencygranulomatous reactionlymphomanecrobiosis lipoidica

Identifiers

PMID41523375

DOI10.7759/cureus.98791

PMCPMC12781958

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